Overlapping but distinct effects of genistein and ethinyl estradiol (EE(2)) in female Sprague-Dawley rats in multigenerational reproductive and chronic toxicity studies.
Overlapping but distinct effects of genistein and ethinyl estradiol (EE(2)) in female Sprague-Dawley rats in multigenerational reproductive and chronic toxicity studies.
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DOI：
10.1016/j.reprotox.2008.12.005
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发表时间：
2009-04
期刊：
影响因子：
--
通讯作者：
Newbold RR
中科院分区：
文献类型：
--
作者：
Delclos KB;Weis CC;Bucci TJ;Olson G;Mellick P;Sadovova N;Latendresse JR;Thorn B;Newbold RR
在多代生殖和慢性毒性研究中检查了染料木黄酮和炔雌醇（EE 2），这些研究在各代之间具有不同的治疗间隔。Sprague-Dawley大鼠在低植物雌激素饮食中接受染料木黄酮（0、5、100或500 ppm）或EE 2（0、2、10或50 ppb）。此处总结了雌性动物的非肿瘤效应。染料木黄酮在500 ppm和EE 2在50 ppb的连续暴露大鼠产生类似的影响，包括体重下降，加速阴道开放，并改变动情周期的年轻动物。在高剂量下，肛门生殖器距离受到两种化合物的微妙影响，并且在染料木黄酮给药动物中窝仔数明显减少。在慢性研究中，相对于对照组，500 ppm的染料木黄酮诱导了异常周期的早期发作。EE 2显著增加子宫病变（非典型局灶性增生和鳞状上皮化生）的发生率。这些化合物特有的影响似乎在前几代接触的后代中得到加强。
Genistein and ethinyl estradiol (EE2) were examined in multigenerational reproductive and chronic toxicity studies that had different treatment intervals among generations. Sprague-Dawley rats received genistein (0, 5, 100, or 500 ppm) or EE2 (0, 2, 10, or 50 ppb) in a low phytoestrogen diet. Nonneoplastic effects in females are summarized here. Genistein at 500 ppm and EE2 at 50 ppb produced similar effects in continuously exposed rats, including decreased body weights, accelerated vaginal opening, and altered estrous cycles in young animals. At the high dose, anogenital distance was subtly affected by both compounds, and a reduction in litter size was evident in genistein-treated animals. Genistein at 500 ppm induced an early onset of aberrant cycles relative to controls in the chronic studies. EE2 significantly increased the incidence of uterine lesions (atypical focal hyperplasia and squamous metaplasia). These compound-specific effects appeared to be enhanced in the offspring of prior exposed generations.
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影响因子：
9.7
作者：
Doerge, DR;Twaddle, NC;Newbold, RR
通讯作者：
Newbold, RR
影响因子：
3.8
作者：
Blair, RM;Fang, H;Sheehan, DM
通讯作者：
Sheehan, DM
影响因子：
3.8
作者：
Casanova, M;You, L;Heck, HD
通讯作者：
Heck, HD
影响因子：
3.3
作者：
Delclos, KB;Bucci, TJ;Newbold, RR
通讯作者：
Newbold, RR
影响因子：
2.9
作者：
BETRABET, SS;SHIKARY, ZK;SAXENA, BN
通讯作者：
SAXENA, BN