Involvement and Possible Role of Eosinophils in Asthma Exacerbation.
Involvement and Possible Role of Eosinophils in Asthma Exacerbation.
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嗜酸性粒细胞在哮喘急性发作中的作用
DOI：
10.3389/fimmu.2018.02220
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发表时间：
2018
影响因子：
7.3
通讯作者：
Nagata M
中科院分区：
文献类型：
--
作者：
Nakagome K;Nagata M
嗜酸性粒细胞参与哮喘恶化的发生。最近的研究表明，痰液和血液嗜酸性粒细胞计数是预测哮喘恶化的重要因素。在严重的嗜酸性粒细胞性哮喘中，抗白细胞介素 (IL)-5 单克隆抗体可降低血液嗜酸性粒细胞计数和哮喘恶化频率。然而，即使没有 IL-5，嗜酸性粒细胞气道炎症也可以通过 T 辅助细胞 (Th) 2 网络充分维持，该网络包含血管细胞粘附分子 1/CC 趋化因子/嗜酸性粒细胞生长因子的级联，包括粒细胞巨噬细胞集落刺激因子 (GM-CSF)。 Periostin 是一种细胞外基质蛋白，也是哮喘中 Th2 免疫反应的生物标志物，可在体外直接激活嗜酸性粒细胞。哮喘恶化的主要原因是病毒感染，尤其是鼻病毒（RV）感染。 RV感染后，上皮细胞上皮细胞上细胞间粘附分子（ICAM）-1的表达增加，ICAM-1是大多数RV的细胞受体，嗜酸性粒细胞对ICAM-1的粘附可以上调嗜酸性粒细胞的功能。半胱氨酰白三烯 (cysLT) 和 CXCL10 的表达在病毒诱发的哮喘中上调。 CysLTs可以在体内直接引起嗜酸性粒细胞浸润并在体外激活嗜酸性粒细胞。此外，嗜酸性粒细胞表达CXC趋化因子受体3，并且CXCL10在体外激活嗜酸性粒细胞。嗜酸性粒细胞和中性粒细胞都会导致严重哮喘或哮喘恶化。 IL-8 是中性粒细胞的重要化学引诱剂，在某些严重哮喘病例中表达上调。脂多糖 (LPS) 可诱导上皮细胞产生 IL-8，在皮质类固醇抵抗性哮喘的下呼吸道中也会增加。即使在没有嗜酸性粒细胞化学引诱剂的情况下，IL-8 或 LPS 刺激的中性粒细胞也会增加嗜酸性粒细胞的跨基底膜迁移。因此，嗜酸性粒细胞可能通过多种机制促进哮喘恶化，包括Th2细胞因子（如IL-5或GM-CSF）或病毒感染相关蛋白（如CXCL10）的激活，以及与其他细胞（如中性粒细胞）的相互作用。
Eosinophils are involved in the development of asthma exacerbation. Recent studies have suggested that sputum and blood eosinophil counts are important factors for predicting asthma exacerbation. In severe eosinophilic asthma, anti-interleukin (IL)-5 monoclonal antibody decreases blood eosinophil count and asthma exacerbation frequency. However, even in the absence of IL-5, eosinophilic airway inflammation can be sufficiently maintained by the T helper (Th) 2 network, which comprises a cascade of vascular cell adhesion molecule-1/CC chemokines/eosinophil growth factors, including granulocyte-macrophage colony-stimulating factor (GM-CSF). Periostin, an extracellular matrix protein and a biomarker of the Th2 immune response in asthma, directly activates eosinophils in vitro. A major cause of asthma exacerbation is viral infection, especially rhinovirus (RV) infection. The expression of intercellular adhesion molecule (ICAM)-1, a cellular receptor for the majority of RVs, on epithelial cells is increased after RV infection, and adhesion of eosinophils to ICAM-1 can upregulate the functions of eosinophils. The expressions of cysteinyl leukotrienes (cysLTs) and CXCL10 are upregulated in virus-induced asthma. CysLTs can directly provoke eosinophilic infiltration in vivo and activate eosinophils in vitro. Furthermore, eosinophils express the CXC chemokine receptor 3, and CXCL10 activates eosinophils in vitro. Both eosinophils and neutrophils contribute to the development of severe asthma or asthma exacerbation. IL-8, which is an important chemoattractant for neutrophils, is upregulated in some cases of severe asthma. Lipopolysaccharide (LPS), which induces IL-8 from epithelial cells, is also increased in the lower airways of corticosteroid-resistant asthma. IL-8 or LPS-stimulated neutrophils increase the transbasement membrane migration of eosinophils, even in the absence of chemoattractants for eosinophils. Therefore, eosinophils are likely to contribute to the development of asthma exacerbation through several mechanisms, including activation by Th2 cytokines, such as IL-5 or GM-CSF or by virus infection-related proteins, such as CXCL10, and interaction with other cells, such as neutrophils.
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影响因子：
4.3
作者：
Barczyk, A;Pierzchala, W;Sozañska, E
通讯作者：
Sozañska, E
DOI：
10.1183/09031936.00092410
发表时间：
2011-05
期刊：
The European respiratory journal
影响因子：
--
作者：
Bizzintino J;Lee WM;Laing IA;Vang F;Pappas T;Zhang G;Martin AC;Khoo SK;Cox DW;Geelhoed GC;McMinn PC;Goldblatt J;Gern JE;Le Souëf PN
通讯作者：
Le Souëf PN
DOI：
10.1164/rccm.200407-894oc
发表时间：
2005-02-15
影响因子：
24.7
作者：
Bisgaard, H;Zielen, S;Polos, P
通讯作者：
Polos, P
影响因子：
6.1
作者：
Bjerregaard, A.;Laing, I. A.;Porsbjerg, C.
通讯作者：
Porsbjerg, C.
影响因子：
15.9
作者：
CALHOUN, WJ;DICK, EC;BUSSE, WW
通讯作者：
BUSSE, WW