Association between human rhinovirus C and severity of acute asthma in children.
Association between human rhinovirus C and severity of acute asthma in children.
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DOI：
10.1183/09031936.00092410
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Le Souëf PN
中科院分区：
文献类型：
--
作者：
Bizzintino J;Lee WM;Laing IA;Vang F;Pappas T;Zhang G;Martin AC;Khoo SK;Cox DW;Geelhoed GC;McMinn PC;Goldblatt J;Gern JE;Le Souëf PN
最近发现了一种新的、潜在更具致病性的人类鼻病毒 (HRV) C 组 (HRVC)。我们假设 HRVC 会出现在患有急性哮喘的儿童中，并且会比其他病毒或 HRV 群体引起更严重的发作。患有急性哮喘的儿童（n = 128，2-16 岁）在急诊室就诊时被招募。评估哮喘恶化的严重程度，并在鼻吸出物中鉴定出呼吸道病毒和 HRV 株。大多数研究儿童患有中度至重度哮喘（85.2%），98.9% 入院治疗。 87.5% 的儿童检测到 HRV，14.8% 的儿童检测到其他呼吸道病毒，其中大多数儿童也患有 HRV。大多数急性哮喘儿童 (59.4%) 都存在 HRVC，并且与更严重的哮喘相关。患有 HRVC 的儿童 (n=76) 的哮喘严重程度评分高于 HRV 感染仅 HRVA 或 HRVB 的儿童 (n=34，p=0.018) 以及所有其他儿童 (n=50，p=0.016)。在 19 名非 HRV 病毒儿童中，13 名同时感染 HRV，其中 7 名是 HRVC。 HRVC 占住院儿童哮喘发作的大部分，并且比以前已知的 HRV 病毒和其他病毒引起更严重的发作。
A new and potentially more pathogenic group of human rhinoviruses (HRV), group C (HRVC) has recently been discovered. We hypothesised that HRVC would be present in children with acute asthma and cause more severe attacks than other viruses or HRV groups. Children with acute asthma (n=128, 2–16 years) were recruited on presentation to an emergency department. Asthma exacerbation severity was assessed and respiratory viruses and HRV strains were identified in a nasal aspirate. The majority of the children studied had moderate to severe asthma (85.2%) and 98.9% were admitted to hospital. HRV was detected in 87.5% and other respiratory viruses in 14.8% of children, most of whom also had HRV. HRVC were present in the majority of children with acute asthma (59.4%) and associated with more severe asthma. Children with HRVC (n=76) had higher asthma severity scores than children whose HRV infection was HRVA or HRVB only (n=34, p=0.018), and all other children (n=50, p=0.016). Of 19 children with a non-HRV virus, 13 had HRV co-infections, seven of these being HRVC. HRVC accounts for the majority of asthma attacks in children presenting to hospital and causes more severe attacks than previously-known HRV groups and other viruses.
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影响因子：
3.7
作者：
Huang T;Wang W;Bessaud M;Ren P;Sheng J;Yan H;Zhang J;Lin X;Wang Y;Delpeyroux F;Deubel V
通讯作者：
Deubel V
DOI：
10.1016/j.jaci.2008.10.007
发表时间：
2009-01
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Miller EK;Edwards KM;Weinberg GA;Iwane MK;Griffin MR;Hall CB;Zhu Y;Szilagyi PG;Morin LL;Heil LH;Lu X;Williams JV;New Vaccine Surveillance Network
通讯作者：
New Vaccine Surveillance Network
DOI：
10.1016/j.jcv.2007.03.012
发表时间：
2007-06
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
McErlean P;Shackelton LA;Lambert SB;Nissen MD;Sloots TP;Mackay IM
通讯作者：
Mackay IM
影响因子：
11.8
作者：
Khetsuriani N;Lu X;Teague WG;Kazerouni N;Anderson LJ;Erdman DD
通讯作者：
Erdman DD
DOI：
10.1513/pats.200701-030aw
发表时间：
2007-07-01
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Johnston, Sebastian L
通讯作者：
Johnston, Sebastian L