Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity.
Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity.
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DOI：
10.1186/1475-2875-7-249
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发表时间：
2008-12-03
期刊：
影响因子：
3
通讯作者：
White, Nicholas J.
中科院分区：
文献类型：
--
作者：
Stepniewska, Kasia;Price, Ric N.;Sutherland, Colin J.;Drakeley, Chris J.;von Seidlein, Lorenz;Nosten, Francois;White, Nicholas J.
本研究的目的是确定和比较在三个不同疟疾流行地区与恶性疟原虫配子细胞携带相关的因素。回顾性数据来自泰国、冈比亚和坦桑尼亚。这些数据来自大型前瞻性现场临床试验，该试验调查了不同抗疟疾药物治疗后配子细胞的携带情况。在观察期间，泰国有12%的患者（7548人中有931人）、冈比亚有34%（2020人中有683人）、坦桑尼亚有31%（1400人中有430人）检测到配子细胞血症（p < 0.001）。在观察期间，大约三分之一（33%,680/2044）的配子细胞血症患者在入组时（第0天或第1天）已经患有专利配子细胞血症：泰国35%(318/931)，冈比亚37%(250/683)，坦桑尼亚26%（112/430）。通常在开始治疗后第7天或之前观察到最大配子细胞血症（泰国93%，坦桑尼亚70%，冈比亚78%）。使用青蒿素衍生物治疗后，配子细胞携带率最低，而磺胺嘧啶-乙胺嘧啶（SP）与配子细胞血症的发生显著高于其他药物治疗（p < 0.001）。泰国和坦桑尼亚的配子体携带时间分别比冈比亚短86%和65%。在贫血患者中，配子体携带时间延长27%，而在接受青蒿素衍生物治疗的患者中，配子体携带时间缩短，在泰国减少27%，在坦桑尼亚和冈比亚减少71%。本研究证实了配子细胞血症与贫血的独立关联，并且在使用青蒿素衍生物治疗后配子细胞携带的患病率和持续时间显著降低。在疟疾传播水平不同的地区，配子体携带率的巨大差异表明，预防传播的药物干预在不同的地方会产生不同的效果。
The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity. Retrospective data from Thailand, The Gambia and Tanzania were used. The data came from large prospective field-based clinical trials, which investigated gametocyte carriage after different anti-malarial drug treatments. Gametocytaemia was detected during the observation period in 12% of patients (931 out of 7548) in Thailand, 34% (683 out of 2020) in The Gambia, and 31% (430 out of 1400) in Tanzania (p < 0.001). Approximately one third (33%, 680/2044) of the patients with gametocytaemia during the observation period, already had patent gametocytaemia at enrolment (day 0 or day 1): 35% (318/931) in Thailand, 37% (250/683) in The Gambia, 26% (112/430) in Tanzania. Maximum gametocytaemia was usually observed on or before the seventh day after starting treatment (93% in Thailand, 70% in Tanzania and 78% in The Gambia). Lowest gametocyte carriage rates were observed following treatment with artemisinin derivatives, while sulphadoxine-pyrimethamine (SP) was associated with significantly greater development of gametocytaemia than other drug treatments (p < 0.001). The duration of gametocyte carriage was shorter in Thailand by 86% and Tanzania by 65% than in The Gambia. Gametocyte carriage was 27% longer among people presenting with anaemia, and was shorter in duration among patients who received artemisinin derivatives, by 27% in Thailand and by 71% in Tanzania and The Gambia. This study confirms the independent association of gametocytaemia with anaemia, and the significantly lower prevalence and duration of gametocyte carriage following treatment with an artemisinin derivative. The large differences in gametocyte carriage rates between regions with different levels of malaria transmission suggest that drug interventions to prevent transmission will have different effects in different places.
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DOI：
10.4269/ajtmh.1991.45.479
发表时间：
1991-10-01
影响因子：
3.3
作者：
GAMAGEMENDIS, AC;RAJAKARUNA, J;MENDIS, KN
通讯作者：
MENDIS, KN
影响因子：
2
作者：
Glidden, DV;Vittinghoff, E
通讯作者：
Vittinghoff, E
影响因子：
6.4
作者：
Meerman, L;Ord, R;Sutherland, CJ
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Sutherland, CJ
DOI：
10.1016/s0035-9203(97)90066-3
发表时间：
1997-05-01
影响因子：
2.2
作者：
Luxemburger, C;Ricci, F;White, N
通讯作者：
White, N
影响因子：
2.4
作者：
BRUCE, MC;ALANO, P;CARTER, R
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CARTER, R