Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma.
Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma.
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DOI：
10.3892/ol.2021.12884
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发表时间：
2021-08
期刊：
影响因子：
2.9
通讯作者：
Ochiya T
中科院分区：
文献类型：
--
作者：
Kohama I;Asano N;Matsuzaki J;Yamamoto Y;Yamamoto T;Takahashi RU;Kobayashi E;Takizawa S;Sakamoto H;Kato K;Fujimoto H;Chikuda H;Kawai A;Ochiya T
肉瘤是一种罕见的癌症，有几种亚型，因此，我们对肉瘤的发病机制了解有限，设计有效的治疗方法也很困难。循环中的microRNAs(MiRNAs)，包括外体miRNAs，作为癌症的生物标志物已经引起了人们的关注。然而，miRNAs和外切体在肉瘤中的作用仍不清楚。对骨肉瘤、尤文氏肉瘤和去分化脂肪肉瘤组织和血清中miRNA表达的分析表明，miR-1246、−4532、−4454、−619-5p和−6126是去分化脂肪肉瘤的生物标志物。这些miRNAs在人DDLPS细胞株和外体中高表达，提示它们是由DDLPS组织分泌的。提示特异性miRNAs可作为DDLPS早期诊断或治疗靶点的生物标志物。
Sarcoma is a rare cancer with several subtypes; therefore, our understanding of the pathogenesis of sarcoma is limited, and designing effective treatments is difficult. Circulating microRNAs (miRNAs), including exosomal miRNAs, have attracted attention as biomarkers in cancer. However, the roles of miRNAs and exosomes in sarcoma remain unclear. The present analysis of tissue and serum miRNA expression in osteosarcoma, Ewing's sarcoma and dedifferentiated liposarcoma (DDLPS) identified miR-1246, −4532, −4454, −619-5p and −6126 as biomarkers for DDLPS. These miRNAs were highly expressed in human DDLPS cell lines and exosomes, suggesting that they are secreted from DDLPS tissues. The present results suggested that specific miRNAs may be used as biomarkers for early diagnosis or treatment targets in DDLPS.
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癌症中的microRNA生物发生途径。
DOI：
10.1038/nrc3932
发表时间：
2015-06
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Lin S;Gregory RI
通讯作者：
Gregory RI
影响因子：
6.2
作者：
Lee, D. H.;Amanat, S.;Koeffler, H. P.
通讯作者：
Koeffler, H. P.
影响因子：
5.7
作者：
Usuba W;Urabe F;Yamamoto Y;Matsuzaki J;Sasaki H;Ichikawa M;Takizawa S;Aoki Y;Niida S;Kato K;Egawa S;Chikaraishi T;Fujimoto H;Ochiya T
通讯作者：
Ochiya T
影响因子：
11.2
作者：
Kanlikilicer P;Rashed MH;Bayraktar R;Mitra R;Ivan C;Aslan B;Zhang X;Filant J;Silva AM;Rodriguez-Aguayo C;Bayraktar E;Pichler M;Ozpolat B;Calin GA;Sood AK;Lopez-Berestein G
通讯作者：
Lopez-Berestein G
影响因子：
1.6
作者：
Fei, Dan;Li, Yang;Gao, Zhongli
通讯作者：
Gao, Zhongli