Pulmonary function and outcomes in infants randomized to a rescue course of antenatal steroids.
Pulmonary function and outcomes in infants randomized to a rescue course of antenatal steroids.
复制标题
DOI：
10.1002/ppul.23711
复制
发表时间：
2017-09
影响因子：
3.1
通讯作者：
Durand M
中科院分区：
文献类型：
--
作者：
McEvoy C;Schilling D;Spitale P;O'Malley J;Bowling S;Durand M
我们的目的是对母亲随机接受产前类固醇 (AS) 与安慰剂单一抢救疗程的早产儿进行 1-2 岁时的后续肺功能测试和临床呼吸结局评估。随机双盲试验的后续行动。在最初的试验中，AS 初始病程≥14 天后的孕妇被随机分配接受救援 AS 或安慰剂。肺功能测试和标准化呼吸系统 对 96 名（87%）幸存者进行了呼吸系统问卷调查。百分之七十七的可用患者进行了肺功能测试。喘息、哮喘的发生率在各组之间没有显着差异，问卷是在校正年龄1-2岁时获得的。呼吸顺应性（Crs）通过单次呼吸闭塞测量，功能残气量（FRC）通过氮气冲洗法测量。分析是按意向治疗进行的。呼吸道合胞病毒感染、呼吸道再入院、使用支气管扩张剂或其他药物，或测量肺功能。研究时的校正年龄、种族、性别或肺功能测试时的身长也没有显着差异。与安慰剂相比，救援组的婴儿具有可比的平均 FRC（249.4 mL 与 246.2 mL；调整后的 95% CI 差异为 -15.45, 38.20；p = 0.37）。潮气量或 Crs 没有差异。 AS 的抢救过程可在 72 小时内显着增加 Crs，并减少新生儿的氧气需求，且不会对 1-2 岁时的肺功能或临床呼吸结果产生不利影响。 [NCT00669383]。
Our objective was to obtain follow-up pulmonary function testing and assessment of clinical respiratory outcomes, at 1–2 years, in preterm infants whose mothers were randomized to a single rescue course of antenatal steroids (AS) versus placebo. Follow-up of a randomized, double-blinded trial. In the original trial pregnant women ≥ 14 days after initial course of AS were randomized to rescue AS or placebo. Pulmonary function testing and a standardized respiratory 96 (87%) of available survivors were administered a respiratory questionnaire. Seventy-seven percent of available patients had pulmonary function testing performed. There was no significant difference between groups in incidence of wheezing, asthma, questionnaire were obtained at 1–2 years of corrected age. Respiratory compliance (Crs) was measured with the single-breath occlusion and functional residual capacity (FRC) with the nitrogen washout method. Analysis was by intention-to-treat. respiratory syncytial virus infection, respiratory readmissions, use of bronchodilators or other medications, or in measurements of pulmonary function. There was also no significant difference in corrected age at study, race, gender, or length at the time of pulmonary function testing. Infants in the rescue group had a comparable mean FRC (249.4 mL versus 246.2 mL; adjusted 95% CI for difference −15.45, 38.20; p =0.37) versus placebo. There were no differences in tidal volume or Crs. A rescue course of AS significantly increases Crs within 72 hours of age and decreases oxygen need in newborn infants, without an adverse impact on pulmonary function or clinical respiratory outcomes at 1–2 years of age. [NCT00669383].
登录
查看更多内容
早产婴儿的医院出院时肺功能随机分为产前类固醇的单个救援过程。
DOI：
10.1016/j.jpeds.2016.10.022
发表时间：
2017-02
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Jordan BK;Schilling D;McEvoy CT
通讯作者：
McEvoy CT
DOI：
10.1164/rccm.200908-1190oc
发表时间：
2010-05-15
影响因子：
24.7
作者：
Balinotti, Juan E.;Chakr, Valentina C.;Tepper, Robert S.
通讯作者：
Tepper, Robert S.
DOI：
10.1164/ajrccm.155.1.9001304
发表时间：
1997-01-01
影响因子：
24.7
作者：
Baraldi, E;Filippone, M;Zacchello, F
通讯作者：
Zacchello, F
影响因子：
5.1
作者：
McEvoy, Cindy;Venigalla, Sridevi;Thuan Nguyen
通讯作者：
Thuan Nguyen
影响因子：
24.3
作者：
Gappa, M;Colin, AA;Stocks, J
通讯作者：
Stocks, J