Inflammation in Chronic Wounds.

Inflammation in Chronic Wounds.
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DOI:
10.3390/ijms17122085
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发表时间:
2016-12-11
影响因子:
5.6
通讯作者:
Xue M
Xue M
中科院分区:
生物学2区
文献类型:
--
作者:
Zhao R;Liang H;Clarke E;Jackson C;Xue M

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不愈合的慢性伤口给个体患者和更广泛的卫生系统带来了重大的生物、心理、社会和经济负担。病理上广泛的炎症在正常愈合级联的破坏中起着重要作用。慢性伤口(静脉、动脉、压力和糖尿病溃疡)的原因可以通过正常愈合和慢性伤口内常见成分(衰老、缺氧、缺血再灌注损伤和细菌定植)产生的异常炎症反应的并列来检查。目前通过清创、敷料和抗生素进行伤口床护理形成了基本的治疗方式。尽管最近遇到了挫折,药物辅助剂仍成为一个有趣的研究领域。
Non-healing chronic wounds present a major biological, psychological, social, and financial burden on both individual patients and the broader health system. Pathologically extensive inflammation plays a major role in the disruption of the normal healing cascade. The causes of chronic wounds (venous, arterial, pressure, and diabetic ulcers) can be examined through a juxtaposition of normal healing and the rogue inflammatory response created by the common components within chronic wounds (ageing, hypoxia, ischaemia-reperfusion injury, and bacterial colonisation). Wound bed care through debridement, dressings, and antibiotics currently form the basic mode of treatment. Despite recent setbacks, pharmaceutical adjuncts form an interesting area of research.
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发表时间: 1997-04-01
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