Point prevalence of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae in Maryland.
Point prevalence of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae in Maryland.
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DOI：
10.1086/675610
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发表时间：
2014-04
影响因子：
4.5
通讯作者：
Maryland Multidrug-Resistant Organism Prevention Collaborative
中科院分区：
文献类型：
--
作者：
Johnson JK;Wilson LE;Zhao L;Richards K;Thom KA;Harris AD;Maryland Multidrug-Resistant Organism Prevention Collaborative
碳青霉烯类耐药肠杆菌科 (CRE) 已成为美国各地与医疗保健相关的重要多重耐药病原体。 1 肺炎克雷伯菌、产碳青霉烯酶肠杆菌科 (KPC) 是美国此类感染的抗生素耐药性的主要微生物。 2 含有碳青霉烯类耐药基因的细菌菌株已对所有已知的一线治疗方案表现出耐药性，这些微生物传播的威胁引起了美国医疗保健系统的高度关注。 3 KPC 的定植和感染与多种医疗保健相关因素有关，并且已记录相关发病率和死亡率的增加。 4 尽管金伯利保护团声名狼藉，但它的真正负担尚不清楚。定植患者是 CRE 的重要储存库，是了解这些生物体传播和控制的关键。在这项研究中，我们通过进行全州范围内的前瞻性横断面流行率调查来确定马里兰州 KPC 的负担，从而确定了居住在所有医疗机构（急性和长期护理）的一组机械通气患者中 KPC 的定植流行率。
Carbapenem-resistant Enterobacteriaceae (CRE) have emerged as significant healthcareassociated multidrug-resistant pathogens across the United States. 1 Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae (KPCs) are the primary organisms of antibiotic resistance for this type of infection in the US. 2 Bacterial strains that harbor carbapenem resistance genes have shown resistance to all known first line therapeutic options and the threat of the spread of these organisms is of great concern to the US healthcare system. 3 Colonization and infection with KPCs have been associated with several healthcare-associated factors, and an increase in associated morbidity and mortality has been documented. 4Despite its notoriety, the true burden of KPCs is unknown. The colonized patient is an important reservoir of CREs and represents a key to understanding the spread and control of these organisms. In this study, we determined the colonization prevalence of KPCs in a cohort of mechanically ventilated patients residing in all healthcare settings (acute and long term care) by performing a statewide prospective cross-sectional prevalence survey to determine the burden of KPCs in Maryland.
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影响因子：
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作者：
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通讯作者：
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作者：
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