Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification.

Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification.
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DOI:
10.1177/1740774520941419
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发表时间:
2020-10
期刊:
Clinical trials (London, England)
影响因子:
--
通讯作者:
Weir CJ
Weir CJ
中科院分区:
其他
文献类型:
--
作者:
Parker RA;Weir CJ

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目前,对于是否应该在不同治疗的多组试验中调整多重测试,缺乏共识和不确定性。提出了一个详细的理由,说明在这种情况下不作调整是合理的。我们认为,在不同治疗的简单多组试验中,非调整应该是默认的起始位置。
There is currently a lack of consensus and uncertainty about whether one should adjust for multiple testing in multi-arm trials of distinct treatments. A detailed rationale is presented to justify non-adjustment in this situation. We argue that non-adjustment should be the default starting position in simple multi-arm trials of distinct treatments.
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