Ruthenium Complexes as Promising Candidates against Lung Cancer.
Ruthenium Complexes as Promising Candidates against Lung Cancer.
复制标题
钌配合物作为抗肺癌的有希望的候选者
DOI：
10.3390/molecules26154389
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发表时间：
2021-07-21
期刊：
影响因子：
--
通讯作者：
Zhang Q
中科院分区：
文献类型：
--
作者：
Sun Q;Li Y;Shi H;Wang Y;Zhang J;Zhang Q
肺癌是死亡率最高、发病率仅次于乳腺癌的常见恶性肿瘤之一，严重威胁人类健康。20世纪60年代初，顺铂的抗肿瘤特性的意外发现引起了人们对用于癌症治疗的金属化合物越来越大的兴趣。但顺铂严重的毒副作用和耐药性限制了其临床应用。因此，已经开发了其他过渡金属络合物用于治疗不同的恶性癌症。其中，钌（II/III）为基础的配合物已成为有前途的抗癌药物候选人，由于其潜在的抗癌性能和选择性的细胞毒活性。本文综述了近年来Ru（II/III）配合物抗肺癌的研究进展，重点介绍了Ru（II/III）配合物诱导肺癌细胞凋亡、坏死性凋亡、自噬、细胞周期阻滞、抑制细胞增殖、侵袭转移等生物学活性的机制。
Lung cancer is one of the most common malignancies with the highest mortality rate and the second-highest incidence rate after breast cancer, posing a serious threat to human health. The accidental discovery of the antitumor properties of cisplatin in the early 1960s aroused a growing interest in metal-based compounds for cancer treatment. However, the clinical application of cisplatin is limited by serious side effects and drug resistance. Therefore, other transition metal complexes have been developed for the treatment of different malignant cancers. Among them, Ru(II/III)-based complexes have emerged as promising anticancer drug candidates due to their potential anticancer properties and selective cytotoxic activity. In this review, we summarized the latest developments of Ru(II/III) complexes against lung cancer, focusing mainly on the mechanisms of their biological activities, including induction of apoptosis, necroptosis, autophagy, cell cycle arrest, inhibition of cell proliferation, and invasion and metastasis of lung cancer cells.
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影响因子：
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作者：
Chen L;Li G;Peng F;Jie X;Dongye G;Cai K;Feng R;Li B;Zeng Q;Lun K;Chen J;Xu B
通讯作者：
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影响因子：
4.6
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通讯作者：
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影响因子：
1.2
作者：
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通讯作者：
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