Reflex response to imposed bilateral hip oscillations in human spinal cord injury.
Reflex response to imposed bilateral hip oscillations in human spinal cord injury.
复制标题
对人类脊髓损伤中施加的双侧髋关节振荡的反射反应。
DOI：
10.1152/jn.00461.2007
复制
发表时间：
2007
影响因子：
2.5
通讯作者：
Schmit,BrianD
中科院分区：
文献类型：
--
作者：
Onushko,Tanya;Schmit,BrianD
在人类脊髓损伤（SCI），强加的单侧髋关节运动触发多关节，协调反射，可能会纳入神经元间的电路参与正常的运动控制，如神经通路与运动的反射控制。为了进一步研究这些髋关节触发反射的复杂性，我们测量了11名慢性SCI受试者对侧髋关节运动学对这种类型的痉挛反射活动的影响。设计了一种新型的髋关节驱动系统，在膝关节和踝关节固定在装有仪器的腿部支架上的同时，施加双侧髋关节振荡。在施加髋关节振荡过程中记录表面肌电图（EMG）和关节扭矩。在两种不同频率下进行测试以测试反射的速度依赖性，并且使用以下四种范式来检查对侧髋传入对髋触发的痉挛反射的影响：1）双侧交替，2）双侧同步，3）在髋伸展时对侧腿保持静止的单侧腿部振荡，以及4）在髋屈曲时对侧腿保持静止的单侧腿部振荡。对双侧交替运动的反应幅度显著大于对双侧同步运动的反应幅度（P< 0.001）。单侧腿部扰动产生的反射模式与交替和同步髋关节振荡期间观察到的反射模式一致。这些观察结果表明，痉挛反射兴奋性调制通过传入输入从对侧髋关节的方式，一般是一致的运动。
In human spinal cord injury (SCI), imposed unilateral hip movements trigger multijoint, coordinated reflexes that might incorporate interneuronal circuitry involved in normal motor control, such as neural pathways associated with the reflex control of locomotion. To further investigate the complexity of these hip-triggered reflexes, we measured the effects of kinematics of the contralateral hip on this type of spastic reflex activity in 11 chronic SCI subjects. A novel servomotor drive system was constructed to impose bilateral hip oscillations while the knees and ankles were held stationary in instrumented leg braces. Surface electromyograms (EMGs) and joint torques were recorded during the imposed hip oscillations. Tests were conducted at two different frequencies to test for velocity dependence of the reflexes and the following four paradigms were used to examine the effects of contralateral hip afferents on hip-triggered spastic reflexes:1) bilateral alternating,2) bilateral synchronous,3) unilateral leg oscillation with the contralateral leg held stationary in hip extension, and4) unilateral leg oscillation with the contralateral leg held stationary in hip flexion. The response to bilateral alternating movements resulted in a significantly larger reflex magnitude compared with the bilateral synchronous movements (P< 0.001). Unilateral leg perturbations yielded reflex patterns that were consistent with the reflex patterns observed during alternating and synchronous hip oscillations. These observations suggest that spastic reflex excitability is modulated through afferent input from the contralateral hip in a manner that is generally consistent with locomotion.
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影响因子：
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作者：
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