Vitamin E enhances the lymphatic transport of beta-carotene and its conversion to vitamin A in the ferret.
Vitamin E enhances the lymphatic transport of beta-carotene and its conversion to vitamin A in the ferret.
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维生素 E 增强雪貂体内 β-胡萝卜素的淋巴运输及其向维生素 A 的转化。
DOI：
10.1016/0016-5085(95)90444-1
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发表时间：
1995
期刊：
影响因子：
29.4
通讯作者：
Russell,RM
中科院分区：
文献类型：
--
作者：
Wang,XD;Marini,RP;Hebuterne,X;Fox,JG;Krinsky,NI;Russell,RM
Background/Aimsβ-Carotene and α-tocopherol may have either antagonistic or synergistic effects on each other's absorption and metabolism. The effects of both physiological and pharmacological concentrations of α-tocopherol on the absorption and metabolism of β-carotene in ferret intestine were determined.MethodsA high concentration of β-carotene was perfused through the upper portion of the small intestine of ferrets in vivo with varying levels of α-tocopherol. The effluent of a mesenteric lymph duct cannulation, the intestinal mucosa scraping, and portal vein blood were sampled and analyzed by high-performance liquid chromatography.ResultsThe lymphatic transport of β-carotene was enhanced 4-fold by α-tocopherol at a physiological dose and 12–21-fold at a pharmacological dose. The lymphatic transport of α-tocopherol was linearly (r = 0.8; P < 0.05) related to the luminal α-tocopherol concentration even in the presence of a high concentration of β-carotene. Furthermore, α-tocopherol increased the conversion of β-carotene into retinol in the intestine in a dose-dependent manner.Conclusionsα-Tocopherol has a positive effect on the intestinal absorption of intact β-carotene and may modulate the metabolic conversion of β-carotene into retinoids.
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维生素 A 代谢：α-生育酚在体内调节组织视黄醇水平，在体外调节棕榈酸视黄酯水解
DOI：
--
发表时间：
1984
期刊：
影响因子：
--
作者：
Joseph L. Napoli;Anne M. McCormick;Brian O'Meara;E. Dratz
通讯作者：
E. Dratz
人类和小鼠长期口服β-胡萝卜素可降低血浆或皮肤α-生育酚浓度。
DOI：
10.1093/jnci/84.20.1559
发表时间：
1992
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Xu,MJ;Plezia,PM;Alberts,DS;Emerson,SS;Peng,YM;Sayers,SM;Liu,Y;Ritenbaugh,C;Gensler,HL
通讯作者：
Gensler,HL
高水平膳食维生素E对大鼠肝脏和血浆脂质以及脂溶性维生素的影响。
DOI：
--
发表时间：
1977
期刊：
Journal of NutriLife
影响因子：
--
作者：
N. Y. Jack Yang;I. Desai
通讯作者：
I. Desai
膳食脂肪和维生素 E 对饲喂过量 β-胡萝卜素的大鼠血浆和肝脏维生素 A 和 β-胡萝卜素水平的影响
DOI：
--
发表时间：
1990
期刊：
影响因子：
--
作者：
B. S. Alam;L. Brown;S. Q. Alam
通讯作者：
S. Q. Alam
回顾：β-胡萝卜素的吸收和代谢。
影响因子：
3.5
作者：
X. Wang
通讯作者：
X. Wang