Review: absorption and metabolism of beta-carotene.

Review: absorption and metabolism of beta-carotene.
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回顾:β-胡萝卜素的吸收和代谢。

DOI:
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发表时间:
1994
影响因子:
3.5
通讯作者:
X. Wang
X. Wang
中科院分区:
医学4区
文献类型:
--
作者:
X. Wang

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为了更好地了解β-胡萝卜素(β-C)在预防癌症中的潜在功能,需要更多的β-C代谢知识和合适的动物模型来模拟人类β-C代谢。小肠粘膜含有β-C裂解酶,从而在β-C的维生素A原活性和抗癌特性中发挥重要作用。雪貂(Mustela putorius furo)吸收完整β-C的能力使其成为研究人类β-C吸收的合适模型。本文综述了β-C在人和雪貂体内的吸收和裂解机制。综述了β-C通过中心裂解和偏心裂解途径合成视黄酸的研究进展。β-C的转换RA作为一种抗癌机制的可能意义进行了讨论。
To better understand the potential function of beta-carotene (beta-C) in the prevention of cancer, greater knowledge of beta-C metabolism and a suitable animal model to mimic human beta-C metabolism are necessary. The small intestinal mucosa contains beta-C cleavage enzyme(s), thereby playing an important role in both the provitamin A activity and anti-cancer properties of beta-C. The ability of the ferret (Mustela putorius furo) to absorb intact beta-C makes it an appropriate model for studying human beta-C absorption. This article reviews the absorption and cleavage mechanisms of beta-C in both the human and the ferret. The biosynthesis of retinoic acid (RA) from beta-C via central and eccentric cleavage pathways is reviewed. The possible significance of the conversion of beta-C to RA as an anticancer mechanism is discussed.
DOI: 10.1021/bi00502a015
发表时间: 1990-12
期刊: Biochemistry
影响因子: 2.9
作者:
Timothy C. Quick;D E Ong
通讯作者: Timothy C. Quick;D E Ong
关于维生素A与癌症关系的一些思考。
DOI: 10.1007/978-1-4613-1835-4_28
发表时间: 1986
影响因子: --
作者:
Olson,JA
通讯作者: Olson,JA
预防癌症的营养方法,重点是维生素、抗氧化剂和类胡萝卜素。
DOI: 10.1093/ajcn/53.1.226s
发表时间: 1991
期刊: The American journal of clinical nutrition
影响因子: --
作者:
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通讯作者: Weisburger,JH
DOI: 10.1093/ajcn/53.1.238s
发表时间: 1991-01-01
影响因子: 7.1
作者:
KRINSKY, NI
通讯作者: KRINSKY, NI
雪貂的肠道灌注β-胡萝卜素会提高门静脉血中的视黄酸水平。
DOI: 10.1016/0005-2760(93)90157-5
发表时间: 1993
期刊: Biochimica et biophysica acta
影响因子: --
作者:
Wang,XD;Russell,RM;Marini,RP;Tang,G;Dolnikowski,GG;Fox,JG;Krinsky,NI
通讯作者: Krinsky,NI