Long-term viral brain-derived neurotrophic factor delivery promotes spasticity in rats with a cervical spinal cord hemisection.
Long-term viral brain-derived neurotrophic factor delivery promotes spasticity in rats with a cervical spinal cord hemisection.
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DOI：
10.3389/fneur.2013.00187
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发表时间：
2013
影响因子：
3.4
通讯作者：
Blesch A
中科院分区：
文献类型：
--
作者：
Fouad K;Bennett DJ;Vavrek R;Blesch A
我们最近报道，大鼠完全胸脊髓损伤（SCI），接受联合治疗，包括病毒性脑源性神经营养因子（BDNF）在脊髓中的交付，不仅表现出增强轴突再生，但也恶化后肢运动功能。通过证明BDNF过表达可以在骶骨SCI大鼠模型中触发痉挛样症状，我们提出了观察到的痉挛样症状之间的因果关系（即，被动活动范围的阻力）和BDNF的过度表达。目前的研究最初是为了评估一个类似的综合治疗大鼠颈椎脊髓损伤，以改善运动恢复。我们再一次发现了类似的痉挛迹象，包括紧握爪子和手腕弯曲。这一发现改变了研究的重点，然后，我们探讨了这种痉挛样症状是否与BDNF拮抗剂的过度表达直接相关。使用肌电图测量，我们表明，这种治疗逐渐减少了阻力，克服前肢屈曲在急性实验。因此，我们的结论是，慢性BDNF的神经兴奋作用，连同减少下降控制SCI后可能会导致不良反应。
We have recently reported that rats with complete thoracic spinal cord injury (SCI) that received a combinatorial treatment, including viral brain-derived neurotrophic factor (BDNF) delivery in the spinal cord, not only showed enhanced axonal regeneration, but also deterioration of hind-limb motor function. By demonstrating that BDNF over-expression can trigger spasticity-like symptoms in a rat model of sacral SCI, we proposed a causal relationship between the observed spasticity-like symptoms (i.e., resistance to passive range of motion) and the over-expression of BDNF. The current study was originally designed to evaluate a comparable combined treatment for cervical SCI in the rat to improve motor recovery. Once again we found similar signs of spasticity involving clenching of the paws and wrist flexion. This finding changed the focus of the study and, we then explored whether this spasticity-like symptom is directly related to the over-expression of BDNF by administering a BDNF antagonist. Using electromyographic measurements we showed that this treatment gradually diminished the resistance to overcome forelimb flexion in an acute experiment. Thus, we conclude that neuro-excitatory effects of chronic BDNF delivery together with diminished descending control after SCI can result in adverse effects.
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影响因子：
16.2
作者：
Kadoya, Ken;Tsukada, Shingo;Lu, Paul;Coppola, Giovanni;Geschwind, Dan;Filbin, Marie T.;Blesch, Armin;Tuszynski, Mark H.
通讯作者：
Tuszynski, Mark H.
影响因子：
5.3
作者：
Houle, John D.;Tom, Veronica J.;Silver, Jerry
通讯作者：
Silver, Jerry
影响因子：
5.3
作者：
Coumans, JV;Lin, TTS;Bregman, BS
通讯作者：
Bregman, BS
影响因子：
5.3
作者：
Grill, RJ;Blesch, A;Tuszynski, MH
通讯作者：
Tuszynski, MH
影响因子：
2.9
作者：
Gulino, R;Lombardo, SA;Perciavalle, V
通讯作者：
Perciavalle, V