Angiogenesis and its targeting in rheumatoid arthritis.
Angiogenesis and its targeting in rheumatoid arthritis.
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DOI：
10.1016/j.vph.2009.02.002
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发表时间：
2009-07
影响因子：
4
通讯作者：
Koch, Alisa E.
中科院分区：
文献类型：
--
作者：
Szekanecz, Zoltan;Koch, Alisa E.
在类风湿性关节炎的发生和发展过程中，血管生成，即新毛细血管的发展，参与白细胞进入滑膜。几种可溶性和细胞表面结合的介质，包括生长因子、细胞因子、趋化因子、蛋白水解基质降解酶、细胞粘附分子等，可以促进滑膜新生血管形成。另一方面，内源性血管生成抑制因子，如血管生成抑制素、内皮抑制素、白细胞介素-4（IL-4）、IL-13、干扰素和一些血管生成抑制趋化因子也在类风湿性滑膜内产生，然而，它们的作用不足以控制滑膜血管生成和炎症。已经开发了几种特异性和非特异性策略来阻断血管生成介质的作用。一线血管生成抑制剂包括血管内皮生长因子（VEGF）、血管生成素、αVβ3整联蛋白拮抗剂，以及非特异性血管生成抑制剂，包括传统疾病调节剂（DMARD）、抗肿瘤坏死因子生物制剂、血管抑素、内皮抑素、烟曲霉素类似物或沙利度胺。任何潜在的血管抑制化合物都可以被引入到关节炎动物模型的研究中，甚至可以被引入到人类类风湿性关节炎的试验中。
Angiogenesis, the development of new capillaries, is involved in leukocyte ingress into the synovium during the development and progression of rheumatoid arthritis. Several soluble and cell surface-bound mediators including growth factors, cytokines, chemokines, proteolytic matrix-degrading enzymes, cell adhesion molecules and others may promote synovial neovascularization. On the other hand, endogenous angiostatic factors, such as angiostatin, endostatin, interleukin-4 (IL-4), IL-13, interferons and some angiostatic chemokines are also produced within the rheumatoid synovium, however, their effects are insufficient to control synovial angiogenesis and inflammation. Several specific and non-specific strategies have been developed to block the action of angiogenic mediators. The first line of angiostatic agents include vascular endothelial growth factor (VEGF), angiopoietin, αVβ3 integrin antagonist, as well as non-specific angiogenesis inhibitors including traditional disease-modifying agents (DMARDs), anti-tumor necrosis factor biologics, angiostatin, endostatin, fumagillin analogues or thalidomide. Potentially any angiostatic compound could be introduced to studies using animal models of arthritis or even to human rheumatoid arthritis trials.
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影响因子：
--
作者：
JOHNSON, BA;HAINES, GK;KOCH, AE
通讯作者：
KOCH, AE
影响因子：
--
作者：
Haas, Christian S.;Amin, M. Asif;Koch, Alisa E.
通讯作者：
Koch, Alisa E.
影响因子：
4.9
作者：
Giatromanolaki, A;Sivridis, E;Koukourakis, MI
通讯作者：
Koukourakis, MI
影响因子：
4.9
作者：
Jacq, Laurent;Garnier, Sophie;Dieude, Philippe;Michou, Laetitia;Pierlot, Celine;Migliorini, Paola;Balsa, Alejandro;Westhovens, Rene;Barrera, Pilar;Alves, Helena;Vaz, Carlos;Fernandes, Manuela;Pascual-Salcedo, Dora;Bombardieri, Stefano;Dequeker, Jan;Radstake, Timothy R;Van Riel, Piet;van de Putte, Leo;Lopes-Vaz, Antonio;Glikmans, Elodie;Barbet, Sandra;Lasbleiz, Sandra;Lemaire, Isabelle;Quillet, Patrick;Hilliquin, Pascal;Teixeira, Vitor Hugo;Petit-Teixeira, Elisabeth;Mbarek, Hamdi;Prum, Bernard;Bardin, Thomas;Cornelis, Francois
通讯作者：
Cornelis, Francois
影响因子：
4.9
作者：
Goedkoop AY;Kraan MC;Picavet DI;de Rie MA;Teunissen MB;Bos JD;Tak PP
通讯作者：
Tak PP