Differential response to genotoxic stress in immortalized or transformed human T-lymphotropic virus type I-infected T-cells.
Differential response to genotoxic stress in immortalized or transformed human T-lymphotropic virus type I-infected T-cells.
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永生化或转化的人类 T 淋巴细胞病毒 I 型感染的 T 细胞对基因毒性应激的差异反应。
DOI：
10.1099/0022-1317-80-7-1575
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Franchini,G
中科院分区：
文献类型：
--
作者：
Cereseto,A;Kislyakova,T;WashingtonParks,R;Nicot,C;Franchini,G
在人类嗜T淋巴细胞病毒I型（HTLV-I）感染的细胞中观察到细胞周期控制机制的几种改变。在此，据报道，HTLV-1感染的细胞在其永生化和转化阶段不经历电离辐射（IR）处理后的细胞凋亡。然而，当IL-2戒断与遗传毒性应激相结合时，处于其永生化阶段（IL-2依赖性）的HTLV-I感染的T细胞经历凋亡，而其转化的对应物（IL-2非依赖性）不经历凋亡。这些结果表明，在转化过程中，HTLV-I感染的T细胞通过获得IL-2受体途径的组成性激活而变得对细胞死亡信号不那么敏感。已知bcl-2和bcl-XL蛋白的表达增加IL-2介导的细胞存活，以及p21 waf 1和p53的表达，在IR后的永生化和转化细胞中没有实质性差异。总之，这些发现表明，由IL-2调节的替代性抗凋亡途径的激活，可能是在永生化的与转化的HTLV-1感染的T细胞中观察到的不同细胞死亡应答的原因。
Several alterations in the mechanism of cell cycle control have been observed in human T-lymphotropic virus type I (HTLV-I)-infected cells. Here, it is reported that HTLV-I-infected cells both in their immortalized and transformed phase do not undergo apoptosis following ionizing radiation (IR) treatment. However, when IL-2 withdrawal is combined with genotoxic stress, HTLV-I-infected T-cells in their immortalized phase (IL-2-dependent) undergo apoptosis where as their transformed counterparts (IL-2-independent) do not. These results suggest that, during the transformation process, the HTLV-I-infected T-cells become less sensitive to cell death signals through the acquisition of constitutive activation of the IL-2 receptor pathway. The expression of bcl-2 and bcl-XL proteins, which are known to increase cell survival mediated by IL-2, as well as of p21waf1 and p53, was not substantially different in immortalized and transformed cells following IR. All together, these findings suggest that activation of alternative anti-apoptotic pathways, regulated by IL-2, might be responsible for the differential cell death response observed in immortalized versus transformed HTLV-I-infected T-cells.
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影响因子：
5.4
作者：
Kenneth G. Low;Lydia F. Dorner;Dinali B. Fernando;Joseph Grossman;K. Jeang;Michael J. Comb
通讯作者：
Kenneth G. Low;Lydia F. Dorner;Dinali B. Fernando;Joseph Grossman;K. Jeang;Michael J. Comb
DOI：
10.1172/jci118193
发表时间：
1995-09
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Xiao Xu;Shin-Heh Kang;O. Heidenreich;Michelle Okerholm;J. O’Shea;M. Nerenberg
通讯作者：
Xiao Xu;Shin-Heh Kang;O. Heidenreich;Michelle Okerholm;J. O’Shea;M. Nerenberg
影响因子：
5.4
作者：
Mulloy, JC;Kislyakova, T;Franchini, G
通讯作者：
Franchini, G
影响因子：
16
作者：
Levkau, B;Koyama, H;Ross, R
通讯作者：
Ross, R
影响因子：
5.4
作者：
AKAGI, T;SHIMOTOHNO, K
通讯作者：
SHIMOTOHNO, K