Long-term urinary adverse effects of pelvic radiotherapy.
Long-term urinary adverse effects of pelvic radiotherapy.
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DOI：
10.1007/s00345-010-0603-x
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发表时间：
2011-02
影响因子：
3.4
通讯作者：
Malaeb, Bahaa S.
中科院分区：
文献类型：
--
作者：
Elliott, Sean P.;Malaeb, Bahaa S.
关键词：
放射治疗盆腔肿瘤已有100多年的历史。放疗（RT）的不良反应（AE）随着时间的推移而不断积累，据报道在治疗后数十年才显示出来。RT治疗盆腔肿瘤的获益已得到充分描述，其急性AE也是如此。晚期AE的描述不太清楚。考虑到RT的高利用率，晚期AE的治疗负担很大。对于前列腺癌，37%的患者将在诊断后的前6个月内接受放疗。据报告，低级别和高级别AE的发生率分别为20- 43%和5- 13%，中位随访时间为10 - 60个月。对于膀胱癌，2级和3级晚期AE分别发生在18-27和6-17%，中位随访时间为29-76个月。对于宫颈癌，放疗后发生低度不良事件的风险可高达28%。高级别AE在3年时发生率约为8%，在20年时发生率为14.4%，或每年约为0.34%。直肠癌和子宫内膜癌放疗后的放疗不良事件似乎不太常见，或至少研究得不多。正确描述盆腔放疗后长期不良事件的发生率有助于为患者提供关于癌症治疗选择的咨询。需要进一步的研究来专门评估长期AE。
Radiation for tumors arising in the pelvis has been utilized for over a 100 years. Adverse effects (AEs) of radiotherapy (RT) continue to accumulate with time and are reported to show decades after treatment. The benefit of RT for pelvic tumors is well described as is their acute AEs. Late AEs are less well described. The burden of treatment for the late AEs is large given the high utilization of RT. For prostate cancer, 37% of patients will receive radiation during the first 6 months after diagnosis. Low-and high-grade AEs are reported to occur in 20–43 and 5–13%, respectively, with a median follow-up of ∼60 months. For bladder cancer, the grade 2 and grade 3 late AEs occur in 18–27 and 6–17% with a median follow-up of 29–76 months. For cervical cancer, the risk of low-grade AEs following radiation can be as high as 28%. High-grade AEs occur in about 8% at 3 years and 14.4% at 20 years or ∼0.34% per year. Radiation AEs appear to be less common or at least less well studied after radiation for rectal and endometrial cancers. Properly delineating the rate of long-term AEs after pelvic RT is instrumental to counseling patients about their options for cancer treatment. Further studies are needed that are powered to specifically evaluate long-term AEs.
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影响因子：
6.6
作者：
Elliott, Sean P.;Meng, Maxwell V.;Carroll, Peter R.
通讯作者：
Carroll, Peter R.
影响因子：
0.3
作者：
Gellrich, J;Hakenberg, OW;Wirth, MR
通讯作者：
Wirth, MR
DOI：
10.1016/0360-3016(95)00118-i
发表时间：
1995-07-30
影响因子：
7
作者：
EIFEL, PJ;LEVENBACK, C;OSWALD, MJ
通讯作者：
OSWALD, MJ
影响因子：
4.7
作者：
Fujikawa, K;Miyamoto, T;Takeuchi, H
通讯作者：
Takeuchi, H
影响因子：
6.2
作者：
Hoskin, PJ;Rojas, AM;Saunders, MI
通讯作者：
Saunders, MI