Distribution of human papillomavirus type 16 variants in human immunodeficiency virus type 1-positive and -negative women.

Distribution of human papillomavirus type 16 variants in human immunodeficiency virus type 1-positive and -negative women.
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人类乳头瘤病毒 16 型变种在人类免疫缺陷病毒 1 型阳性和阴性女性中的分布。

DOI:
10.1099/vir.0.19694-0
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发表时间:
2004
期刊:
The Journal of general virology
影响因子:
--
通讯作者:
Hagensee,MichaelE
Hagensee,MichaelE
中科院分区:
--
文献类型:
--
作者:
Chaturvedi,AnilK;Brinkman,JoeliA;Gaffga,AnnM;Dumestre,Jeanne;Clark,RebeccaA;Braly,PatriciaS;Dunlap,Kathleen;Kissinger,PatriciaJ;Hagensee,MichaelE

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The prevalence of human papillomavirus type 16 E6 variant lineages was characterized in a cross-sectional study of 24 human immunodeficiency virus type 1 (HIV)-positive and 33 HIV-negative women in New Orleans. The European prototype was the predominant variant in the HIV-negative women (39·4 %), while in the HIV-positive women the European 350G variant was predominant (29·1 %). In exact logistic regression models, HIV-positive women were significantly more likely to harbour any variant with a nucleotide G-350 mutation compared with HIV-negative women [58·3 % vs 21·1 %; adjusted odds ratio (AOR)=6·28, 95 % confidence interval (CI)=1·19–46·54]. Models also revealed a trend towards increased prevalence of Asian–American lineage in HIV-positive women compared with HIV-negative women (25·0 % vs 6·0 %; AOR=6·35, 95 % CI=0·77–84·97). No association was observed between any variant and cytology or CD4 cell counts or HIV-1 viral loads. These observations reflect a difference in the distribution of HPV-16 variants among HIV-positive and -negative women, indicating that HIV-positive status may lead to increased prevalence of a subset of variants.
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