Estimation and testing with overdispersed proportions using the beta-logistic regression model of Heckman and Willis.

Estimation and testing with overdispersed proportions using the beta-logistic regression model of Heckman and Willis.
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使用 Heckman 和 Willis 的 beta-logistic 回归模型对过度分散的比例进行估计和测试。

DOI:
10.1111/j.0006-341x.2000.00125.x
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发表时间:
2000
期刊:
Biometrics.
影响因子:
--
通讯作者:
Durham,SD
Durham,SD
中科院分区:
--
文献类型:
--
作者:
Slaton,TL;Piegorsch,WW;Durham,SD

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Methods are presented for modeling dose‐related effects in proportion data when extra‐binomial variability is a concern. Motivation is taken from experiments in developmental toxicology, where similarity among conceptuses within a litter leads to intralitter correlations and to overdispersion in the observed proportions. Appeal is made to the well‐known beta‐binomial distribution to represent the overdispersion. From this, an exponential function of the linear predictor is used to model the dose‐response relationship. The specification was introduced previously for econometric applications by Heckman and Willis; it induces a form of logistic regression for the mean response, together with a reciprocal biexponential model for the intralitter correlation. Large‐sample, likelihood‐based methods for estimating and testing the joint proportion‐correlation response are studied. A developmental toxicity data set illustrates the methods.
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