Focal adhesion kinase regulation of neovascularization.
Focal adhesion kinase regulation of neovascularization.
复制标题
局灶性粘附激酶调节新血管形成。
DOI：
10.1016/j.mvr.2011.05.002
复制
发表时间：
2012-01
影响因子：
3.1
通讯作者：
Chatterjee I
中科院分区：
文献类型：
--
作者：
Wary KK;Kohler EE;Chatterjee I
在这篇综述中，我们讨论了粘着斑激酶（FAK），细胞内酪氨酸激酶，在内皮细胞中的作用与新生血管形成。遗传和体外研究已经确定了调节内皮细胞新生血管表型的关键因子、受体系统及其细胞内信号传导组分。在这些因子中，FAK似乎调节内皮细胞行为的几个方面，包括迁移、存活、细胞骨架组织以及细胞增殖。当内皮细胞粘附到细胞外基质（ECM）配体上时，整合素聚集在质膜平面上，而整合素的胞质结构域与细胞骨架蛋白和信号分子（包括FAK）相互作用。然而，FAK不仅作为整合素信号传导的关键组分，而且还是VEGF/VEGF-受体和调节新血管形成的其它配体-受体系统的下游元件。因此，对FAK介导的新生血管形成的完整理解应该涉及调节FAK生物学的分子和细胞机制。因此，对FAK的持续研究可能会产生新的治疗方法，以改善与疾病相关的病理性新生血管形成的治疗方式。
In this review, we discuss the role of focal adhesion kinase (FAK), an intracellular tyrosine kinase, in endothelial cells in relation to neovascularization. Genetic and in vitro studies have identified critical factors, receptor systems, and their intracellular signaling components that regulate the neovasculogenic phenotypes of endothelial cells. Among these factors, FAK appears to regulate several aspects of endothelial cellular behavior, including migration, survival, cytoskeletal organization, as well as cell proliferation. Upon adhesion of endothelial cells to extracellular matrix (ECM) ligands, integrins cluster on the plane of plasma-membrane, while cytoplasmic domains of integrins interact with cytoskeletal proteins and signaling molecules including FAK. However, FAK not only serves as a critical component of integrin signaling, but is also a downstream element of the VEGF/VEGF-receptor and other ligand-receptor systems that regulate neovascularization. A complete understanding of FAK-mediated neovascularization, therefore, should address the molecular and cellular mechanisms that regulate the biology of FAK. Continued research on FAK may, therefore, yield novel therapies to improve treatment modalities for the pathological neovascularization associated with diseases.
登录
查看更多内容
影响因子：
64.8
作者：
Chen, Michael J.;Yokomizo, Tomomasa;Zeigler, Brandon M.;Dzierzak, Elaine;Speck, Nancy A.
通讯作者：
Speck, Nancy A.
影响因子：
1.2
作者：
Hofmann, Jennifer J.;Iruela-Arispe, M. Luisa
通讯作者：
Iruela-Arispe, M. Luisa
DOI：
10.1016/j.bbaexp.2004.03.002
发表时间：
2004-05-25
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
影响因子：
--
作者：
Golubovskaya, V;Kaur, A;Cance, W
通讯作者：
Cance, W
影响因子：
64.8
作者：
Gerber, HP;Malik, AK;Ferrara, N
通讯作者：
Ferrara, N
影响因子：
3.1
作者：
AUSPRUNK, DH;FOLKMAN, J
通讯作者：
FOLKMAN, J