Effects of alterations in energy supply on gluconeogenesis from L-lactate.
Effects of alterations in energy supply on gluconeogenesis from L-lactate.
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能量供应变化对 L-乳酸糖异生的影响。
DOI：
10.1016/0020-711x(82)90014-3
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Rognstad,R
中科院分区：
文献类型：
--
作者：
Rognstad,R
1. We have examined effects, on gluconeogenesis from lactate, of altering energy metabolism in two ways:(a) by primarily lowering cytosolic ATP levels with the use of atractyloside or 2, 5 anhydromannose; and (b) by decreasing mitochondrial energy generation with the use of the classical uncoupler, dinitrophenol. 2. Agents which lower cytosolic ATP inhibit gluconeogenesis and increase pyruvate kinase flux (PK) correspondingly, while pyruvate carboxylase and P-enolpyruvate carboxykinase fluxes are unchanged, at least until gluconeogenesis is inhibited by more than 50%. 3. Dinitrophenol, on the other hand, although it also induces a (smaller) increase in PK, primarily decreases gluconeogenesis by an effect on a mitochondrial step in the gluconeogenic pathway. 4. Low concentrations of dinitrophenol increase Krebs cycle oxidation by at least 50% before significant inhibition of gluconeogenesis from lactate occurs.
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丙酮酸激酶反应的平衡和动力学研究。
影响因子：
4.8
作者：
J. T. McQuate;M. Utter
通讯作者：
M. Utter
分离肝细胞中胰高血糖素对丙酮酸激酶活性的控制。
DOI：
--
发表时间：
1976
期刊：
Biochemical and Biophysical Research Communications - BBRC
影响因子：
--
作者：
J. Riou;T. Claus;S. Pilkis
通讯作者：
S. Pilkis
影响因子：
56.9
作者：
MAENPAA, PH;RAIVIO, KO;KEKOMAKI, MP
通讯作者：
KEKOMAKI, MP
糖异生和酮生成的控制机制。
影响因子：
4.8
作者：
J. Williamson;E. Browning;R. Scholz
通讯作者：
R. Scholz
胰高血糖素治疗刺激肝软骨下颗粒的新陈代谢。
影响因子：
4.8
作者：
M. Titheradge;S. B. Binder;Russell K Yamazaki;R. Haynes
通讯作者：
R. Haynes