Covid-19-related encephalopathy: a case series with brain FDG-PET/CT findings
Covid-19-related encephalopathy: a case series with brain FDG-PET/CT findings
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Covid-19 相关脑病：脑部 FDG-PET/CT 结果病例系列
DOI：
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Valérie Pourcher
中科院分区：
文献类型：
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作者：
C. Delorme;O. Paccoud;A. Kas;A. Hesters;S. Bombois;Pauline Shambrook;Augustin Boullet;Diana Doukhi;L. le Guennec;N. Godefroy;R. Maatoug;P. Fossati;B. Millet;V. Navarro;G. Bruneteau;S. Demeret;Valérie Pourcher
背景技术背景：据报道，多种神经系统表现与COVID-19有关。COVID-19相关脑病很少报告和研究。方法：我们报告了4例新冠肺炎相关脑病病例。诊断是在确诊的新冠肺炎患者中做出的，这些患者表现为新发认知障碍、中枢局灶性神经系统体征或癫痫发作。所有患者均接受认知筛查、脑MRI、腰椎穿刺和脑FDG-PET/CT。研究结果：这四名患者年龄在60岁或以上，有不同程度的认知障碍，主要是额叶障碍。2例患者出现小脑综合征，1例出现肌阵挛，1例出现精神症状，1例出现癫痫持续状态。首次出现新冠肺炎症状和神经系统症状发作之间的延迟时间为0至12天。所有患者均无脑炎的MRI特征，也无明显的CSF异常。所有患者脑脊液SARS-CoV-2 RT-PCR均为阴性。所有患者均表现出一致的脑部FDG-PET/CT异常模式，即额叶低代谢和小脑高代谢。所有患者在免疫治疗后均有所改善。结论：尽管临床表现不同，但所有患者均表现出一致的FDG-PET模式，这可能反映了免疫机制。
BACKGROUND: A variety of neurological manifestations have been reported in association with Covid-19. Covid-19-related encephalopathy has seldom been reported and studied. METHODS: We report four cases of Covid-19-related encephalopathy. The diagnosis was made in patients with confirmed Covid-19 who presented with new-onset cognitive disturbances, central focal neurological signs or seizures. All patients underwent cognitive screening, brain MRI, lumbar puncture, and brain FDG-PET/CT. RESULTS: The four patients were 60 years of age or older, and presented with various degrees of cognitive impairment, with predominant frontal lobe impairment. Two patients presented with cerebellar syndrome, one had myoclonus, one had psychiatric manifestations, and one patient had status epilepticus. The delay between first Covid-19 symptoms and onset of neurological symptoms was between 0 and 12 days. None of the patients had MRI features of encephalitis nor significant CSF abnormalities. SARS-CoV-2 RT-PCR in the CSF was negative for all patients. All patients presented with a consistent brain FDG-PET/CT pattern of abnormalities, namely frontal hypometabolism and cerebellar hypermetabolism. All patients improved after immunotherapy. CONCLUSIONS: Despite varied clinical presentations, all patients presented with a consistent FDG-PET pattern which may reflect an immune mechanism.
影响因子：
2.6
作者：
Berti, Valentina;Mosconi, Lisa;Pupi, Alberto
通讯作者：
Pupi, Alberto