A Naturalistic Study of Driving Behavior in Older Adults and Preclinical Alzheimer Disease: A Pilot Study.
A Naturalistic Study of Driving Behavior in Older Adults and Preclinical Alzheimer Disease: A Pilot Study.
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DOI：
10.1177/0733464817690679
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Roe CM
中科院分区：
文献类型：
--
作者：
Babulal GM;Stout SH;Benzinger TLS;Ott BR;Carr DB;Webb M;Traub CM;Addison A;Morris JC;Warren DK;Roe CM
症状性阿尔茨海默病（AD）的临床后果是驾驶性能受损。然而，驾驶性能的下降可能开始于AD的临床前阶段。我们使用自然主义的驾驶方法来研究一年多的驾驶行为的差异，在一个小样本的认知正常的老年人（n = 10）和没有（n = 10）临床前AD。正如小样本量所预期的那样，两组之间没有统计学显著差异，但临床前AD的老年人驾驶频率较低，不太可能在夜间驾驶，并且具有较少的攻击性行为，如急刹车，超速和突然加速。计算了支持更大研究以确定差异所需的样本量。
A clinical consequence of symptomatic Alzheimer's disease (AD) is impaired driving performance. However, decline in driving performance may begin in the preclinical stage of AD. We used a naturalistic driving methodology to examine differences in driving behavior over one year in a small sample of cognitively normal older adults with (n = 10) and without (n = 10) preclinical AD. As expected with a small sample size, there were no statistically significant differences between the two groups, but older adults with preclinical AD drove less often, were less likely to drive at night, and had fewer aggressive behaviors such as hard braking, speeding, and sudden acceleration. The sample size required to power a larger study to determine differences was calculated.
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影响因子：
5.9
作者：
Eby, David W.;Silverstein, Nina M.;Adler, Geri
通讯作者：
Adler, Geri
影响因子：
11.2
作者：
Klunk, WE;Engler, H;Långström, B
通讯作者：
Långström, B
影响因子：
3
作者：
Chapman, Lyn;Sargent-Cox, Kerry;Anstey, Kaarin J.
通讯作者：
Anstey, Kaarin J.
DOI：
10.1001/jama.2010.2008
发表时间：
2011-01-19
期刊：
JAMA
影响因子：
--
作者：
Clark CM;Schneider JA;Bedell BJ;Beach TG;Bilker WB;Mintun MA;Pontecorvo MJ;Hefti F;Carpenter AP;Flitter ML;Krautkramer MJ;Kung HF;Coleman RE;Doraiswamy PM;Fleisher AS;Sabbagh MN;Sadowsky CH;Reiman EP;Zehntner SP;Skovronsky DM;AV45-A07 Study Group
通讯作者：
AV45-A07 Study Group
影响因子：
11.1
作者：
Fagan, Anne M.;Mintun, Mark A.;Shah, Aarti R.;Aldea, Patricia;Roe, Catherine M.;Mach, Robert H.;Marcus, Daniel;Morris, John C.;Holtzman, David M.
通讯作者：
Holtzman, David M.