Optimization of interneuron function by direct coupling of cell migration and axonal targeting.
Optimization of interneuron function by direct coupling of cell migration and axonal targeting.
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DOI：
10.1038/s41593-018-0162-9
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发表时间：
2018-07
影响因子：
25
通讯作者：
Marín O
中科院分区：
文献类型：
--
作者：
Lim L;Pakan JMP;Selten MM;Marques-Smith A;Llorca A;Bae SE;Rochefort NL;Marín O
神经回路组装依赖于细胞迁移和轴突靶向等发育过程的精确同步，但协调这些事件的细胞自主机制仍然很大程度上未知。在这里，我们发现不同类别的中间神经元使用不同的迁移途径到达胚胎大脑皮层。通过边缘区迁移的表达生长抑素的中间神经元发育成马蒂诺蒂细胞，这是最独特的皮质中间神经元类型之一。对于这些细胞来说，通过边缘区的迁移与其特征性的第 1 层轴突树枝化的发育有关。通过条件性删除 Mafb（这些细胞优先表达的基因）来改变 Martinotti 细胞的正常迁移路线，细胞自主地破坏轴突发育并损害这些细胞在体内的功能。我们的结果表明，迁移和轴突靶向程序相结合以优化大脑皮层中抑制电路的组装。
Neural circuit assembly relies on the precise synchronization of developmental processes such as cell migration and axon targeting, but the cell autonomous mechanisms coordinating these events remain largely unknown. Here we found that different classes of interneurons use distinct routes of migration to reach the embryonic cerebral cortex. Somatostatin-expressing interneurons that migrate through the marginal zone develop into Martinotti cells, one of the most distinctive class of cortical interneurons. For these cells, migration through the marginal zone is linked to the development of their characteristic layer 1 axonal arborization. Alteration of the normal migratory route of Martinotti cells by conditional deletion of Mafb – a gene that is preferentially expressed by these cells – cell-autonomously disrupts axonal development and impairs the function of these cells in vivo. Our results suggest that migration and axon targeting programs are coupled to optimize the assembly of inhibitory circuits in the cerebral cortex.
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DOI：
10.1126/science.aac9462
发表时间：
2015-11-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jiang X;Shen S;Cadwell CR;Berens P;Sinz F;Ecker AS;Patel S;Tolias AS
通讯作者：
Tolias AS
影响因子：
16.2
作者：
Jacobson, C;Schnapp, B;Banker, GA
通讯作者：
Banker, GA
影响因子：
3.4
作者：
Gelman, Diego M.;Marin, Oscar
通讯作者：
Marin, Oscar
影响因子：
25
作者：
Madisen L;Zwingman TA;Sunkin SM;Oh SW;Zariwala HA;Gu H;Ng LL;Palmiter RD;Hawrylycz MJ;Jones AR;Lein ES;Zeng H
通讯作者：
Zeng H
DOI：
10.1083/jcb.201408056
发表时间：
2015-02-02
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bentley M;Decker H;Luisi J;Banker G
通讯作者：
Banker G