Renal diseases and the role of complement: Linking complement to immune effector pathways and therapeutics.
Renal diseases and the role of complement: Linking complement to immune effector pathways and therapeutics.
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DOI：
10.1016/bs.ai.2021.09.001
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发表时间：
2021
影响因子：
--
通讯作者：
Afzali B
中科院分区：
文献类型：
--
作者：
Freiwald T;Afzali B
补体系统是一种古老的、在遗传学上保守的关键危险感应系统，对于宿主防御病原体至关重要。补体系统的激活是检测和清除病原体所需的先天免疫的重要组成部分。它也是适应性免疫反应的中心协调者和正常组织稳态的组成部分。一旦发生补体激活，该系统不加选择地沉积在附近的任何细胞表面上，并有可能引起不必要的和过度的组织损伤。补体成分的沉积被认为是各种肾脏疾病的标志，其中它确实与对自身的损害有关。补体在每种肾脏疾病中的起源和病理生理作用尚未完全了解。然而，近年来，补体的研究出现了复兴，人们更加重视其作为细胞内在系统的细胞内作用及其与免疫效应途径的相互作用。这已经与大量拮抗补体组分的新型治疗剂配对，包括针对补体组分（C）1、C3、C5和C5aR1的批准的抑制剂。许多临床试验已经研究了这些更有针对性的方法用于肾脏疾病的管理。在这篇综述中，我们提出并总结了补体在肾脏疾病中的作用的证据，并讨论了补体抑制的临床证据。
The complement system is an ancient and phylogenetically conserved key danger sensing system that is critical for host defense against pathogens. Activation of the complement system is a vital component of innate immunity required for the detection and removal of pathogens. It is also a central orchestrator of adaptive immune responses and a constituent of normal tissue homeostasis. Once complement activation occurs, this system deposits indiscriminately on any cell surface in the vicinity and has the potential to cause unwanted and excessive tissue injury. Deposition of complement components is recognized as a hallmark of a variety of kidney diseases, where it is indeed associated with damage to the self. The provenance and the pathophysiological role(s) played by complement in each kidney disease is not fully understood. However, in recent years there has been a renaissance in the study of complement, with greater appreciation of its intracellular roles as a cell-intrinsic system and its interplay with immune effector pathways. This has been paired with a profusion of novel therapeutic agents antagonizing complement components, including approved inhibitors against complement components (C)1, C3, C5 and C5aR1. A number of clinical trials have investigated the use of these more targeted approaches for the management of kidney diseases. In this review we present and summarize the evidence for the roles of complement in kidney diseases and discuss the available clinical evidence for complement inhibition.
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影响因子：
16.6
作者：
Arbore G;West EE;Rahman J;Le Friec G;Niyonzima N;Pirooznia M;Tunc I;Pavlidis P;Powell N;Li Y;Liu P;Servais A;Couzi L;Fremeaux-Bacchi V;Placais L;Ferraro A;Walsh PR;Kavanagh D;Afzali B;Lavender P;Lachmann HJ;Kemper C
通讯作者：
Kemper C
影响因子：
13.6
作者：
Al-Rabadi, Laith Farah;Caza, Tiffany;Beck, Laurence H.
通讯作者：
Beck, Laurence H.
影响因子：
30.5
作者：
Arazi, Arnon;Rao, Deepak A.;Goldman, Daniel H.
通讯作者：
Goldman, Daniel H.
T 辅助细胞 1 免疫需要 CD4⁺ T 细胞中补体驱动的 NLRP3 炎性体活性。
DOI：
10.1126/science.aad1210
发表时间：
2016-06-17
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arbore G;West EE;Spolski R;Robertson AAB;Klos A;Rheinheimer C;Dutow P;Woodruff TM;Yu ZX;O'Neill LA;Coll RC;Sher A;Leonard WJ;Köhl J;Monk P;Cooper MA;Arno M;Afzali B;Lachmann HJ;Cope AP;Mayer-Barber KD;Kemper C
通讯作者：
Kemper C
影响因子：
120.7
作者：
BELL, BP;GOLDOFT, M;KOBAYASHI, J
通讯作者：
KOBAYASHI, J