Fronto-Striatal Atrophy in Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease.
Fronto-Striatal Atrophy in Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease.
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DOI：
10.3389/fneur.2015.00147
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发表时间：
2015
影响因子：
3.4
通讯作者：
Hornberger M
中科院分区：
文献类型：
--
作者：
Bertoux M;O'Callaghan C;Flanagan E;Hodges JR;Hornberger M
行为变异性额颞叶痴呆（bvFTD）最近才与显著的纹状体萎缩相关，而纹状体似乎在阿尔茨海默病（AD）中相对保留。考虑到纹状体在认知和行为中的关键作用，纹状体变性以及额叶萎缩可能是bvFTD中一些特征性症状的原因，因此成为区分bvFTD和AD的有前景的新型诊断生物标志物。然而，以前的研究在比较这两种疾病时只考虑了皮质或纹状体萎缩。在本研究中，基于纹状体和皮质区域的结构连接性，我们首次建立了23例bvFTD和29例AD患者就诊时的额-纹状体萎缩特征。通过使用一种新的概率连接图谱将患者与50名健康对照进行比较，该图谱通过皮质白质连接定义纹状体区域，使我们能够探索功能相关的额叶和纹状体区域的退化。与对照组相比，bvFTD显示显著的额-纹状体萎缩，影响腹侧以及前后背外侧前额叶皮质和相关纹状体亚区。相比之下，AD显示很少的额-纹状体萎缩，尽管有显着的后背外侧前额叶变性。bvFTD和AD之间的直接比较显示，bvFTD的腹侧纹状体-腹内侧前额叶皮质区域萎缩显著更多。因此，腹侧额-纹状体区的缺陷成为bvFTD有前景的新型有效诊断生物标志物。需要进一步研究这些额-纹状体回路对bvFTD神经学的贡献，以开发简单的诊断和疾病跟踪算法。
Behavioral variant frontotemporal dementia (bvFTD) has only recently been associated with significant striatal atrophy, whereas the striatum appears to be relatively preserved in Alzheimer’s disease (AD). Considering the critical role the striatum has in cognition and behavior, striatal degeneration, together with frontal atrophy, could be responsible of some characteristic symptoms in bvFTD and emerges therefore as promising novel diagnostic biomarker to distinguish bvFTD and AD. Previous studies have, however, only taken either cortical or striatal atrophy into account when comparing the two diseases. In this study, we establish for the first time a profile of fronto-striatal atrophy in 23 bvFTD and 29 AD patients at presentation, based on the structural connectivity of striatal and cortical regions. Patients are compared to 50 healthy controls by using a novel probabilistic connectivity atlas, which defines striatal regions by their cortical white-matter connectivity, allowing us to explore the degeneration of the frontal and striatal regions that are functionally linked. Comparisons with controls revealed that bvFTD showed substantial fronto-striatal atrophy affecting the ventral as well as anterior and posterior dorso-lateral prefrontal cortices and the related striatal subregions. In contrast, AD showed few fronto-striatal atrophy, despite having significant posterior dorso-lateral prefrontal degeneration. Direct comparison between bvFTD and AD revealed significantly more atrophy in the ventral striatal–ventromedial prefrontal cortex regions in bvFTD. Consequently, deficits in ventral fronto-striatal regions emerge as promising novel and efficient diagnosis biomarker for bvFTD. Future investigations into the contributions of these fronto-striatal loops on bvFTD symptomology are needed to develop simple diagnostic and disease tracking algorithms.
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影响因子：
4.2
作者：
Dalton, Marshall A.;Weickert, Thomas W.;Hornberger, Michael
通讯作者：
Hornberger, Michael
影响因子：
11
作者：
Bozeat, S;Gregory, CA;Hodges, JR
通讯作者：
Hodges, JR
DOI：
10.1016/j.jalz.2012.09.010
发表时间：
2013-10-01
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Bertoux, Maxime;Funkiewiez, Aurelie;Hornberger, Michael
通讯作者：
Hornberger, Michael
影响因子：
2.6
作者：
Diekhof, Esther Kristina;Kaps, Lisa;Gruber, Oliver
通讯作者：
Gruber, Oliver
影响因子：
2.8
作者：
Eslinger PJ;Moore P;Antani S;Anderson C;Grossman M
通讯作者：
Grossman M