Domesticated transposable element gene products in human cancer
Domesticated transposable element gene products in human cancer
复制标题
人类癌症中驯化的转座元件基因产物
DOI：
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复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
A. Dupuy
中科院分区：
文献类型：
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作者：
J. Riordan;A. Dupuy
对插入到基因组中的转座元件进行改造，以在宿主细胞中发挥新的功能，这一过程被称为分子驯化，这是自然界中一种普遍存在的现象。通过这种机制，在人类中产生了大约50个蛋白质编码基因。对这些驯化基因的功能描述表明，它们参与了多种不同的细胞过程。其中一些功能与细胞活动和已知的参与癌症发展的途径有关。在这篇简短的综述中，我们讨论了驯化基因在人类癌症中可能被异常调控的作用，以及已发现在肿瘤中表达中断的研究。我们还描述了为转座元件衍生基因产物促进肿瘤发生提供了确凿的实验证据的研究。
The adaptation of transposable elements inserted within the genome to serve novel functions in a host cell, a process known as molecular domestication, is a widespread phenomenon in nature. Around fifty protein-coding genes in humans have arisen through this mechanism. Functional characterization of these domesticated genes has revealed involvement in a multitude of diverse cellular processes. Some of these functions are related to cellular activities and pathways known to be involved in cancer development. In this mini-review we discuss such roles of domesticated genes that may be aberrantly regulated in human cancer, as well as studies that have identified disrupted expression in tumors. We also describe studies that have provided definitive experimental evidence for transposable element-derived gene products in promoting tumorigenesis.
影响因子：
14.5
作者：
Belancio VP;Roy-Engel AM;Deininger PL
通讯作者：
Deininger PL
DOI：
10.1016/j.mrfmmm.2006.11.021
发表时间：
2007-03-01
影响因子：
2.3
作者：
Hedges, D. J.;Deininger, P. L.
通讯作者：
Deininger, P. L.