Mycoplasma Pneumoniae Infection and Persistent Wheezing in Young Children: A Retrospective Case-Control Study.
Mycoplasma Pneumoniae Infection and Persistent Wheezing in Young Children: A Retrospective Case-Control Study.
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幼儿肺炎支原体感染与持续性喘息：一项回顾性病例对照研究
DOI：
10.3389/fped.2022.811086
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发表时间：
2022
影响因子：
2.6
通讯作者：
Chen Z
中科院分区：
文献类型：
--
作者：
Sun H;Li S;Wang T;Chen Z
探讨支气管肺泡灌洗液（BALF）中肺炎支原体（MP）DNA检测的持续性喘息（PW）儿童的临床特征。这项回顾性病例对照研究包括连续入院的3岁以下儿童，他们被诊断为PW，并在BALF中检测到MP DNA。肺炎支原体肺炎（MPP）和异物吸入（FBA）患者作为对照。比较各组的临床特点。在研究期间，有89例被诊断为PW的患者没有传导性气道结构异常，并选择其中30例（33.7%，30/89）在BALF中检测到MP DNA的患者作为研究组。我们纳入了44例MPP患者和44例FBA患者作为对照。MPP组患者年龄较大，发热和C反应蛋白（CRP）的发生率高于PW组（均P < 0.001）。MPP组MP DNA拷贝数中位数高于PW组（P = 0.004）。PW组MP IgG中位数低于MPP组，高于FBA组（均P < 0.001）。MP DNA拷贝数与年龄（r = 0.392，P = 0.001）和CRP（r = 0.235，P = 0.048）呈正相关。我们的研究表明，PW患者的支气管肺泡灌洗液中MP含量很高。此外，MP感染负荷低的年轻患者显示较低的抗体量，并且弱的炎症反应可能与PW相关。
To investigate the clinical characteristics of children with persistent wheezing (PW) with Mycoplasma pneumoniae (MP) DNA in bronchoalveolar lavage fluid (BALF). This retrospective case-control study included consecutive admitted children under 3 years of age who were diagnosed with PW and had MP DNA detected in BALF. Patients with mycoplasma pneumoniae pneumonia (MPP) and foreign-body aspiration (FBA) were enrolled as controls. The clinical characteristics of the groups were compared. During the study period, there were 89 patients diagnosed with PW without structural anomalies of the conductive airways, and 30 of these patients (33.7%, 30/89) with MP DNA detected in the BALF were selected as the study group. We included 44 patients with MPP and 44 patients with FBA as controls. Patients with MPP were older and had a higher occurrence of fever and C-reactive protein (CRP) than patients with PW (all P < 0.001). The median MP DNA copy number in patients with MPP was higher than that of patients with PW (P = 0.004). The median level of MP IgG in patients with PW was lower than that of patients with MPP and higher than that of patients with FBA (all P < 0.001). MP DNA copy number positively correlated with age (r = 0.392, P = 0.001) and CRP (r = 0.235, P = 0.048). Our study reveals that MP was highly detected in the BALF of PW patients. In addition, young patients with a low load of MP infection showed lower amounts of antibody, and a weak inflammatory response might be associated with PW.
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影响因子：
9.6
作者：
Le Bourgeois, M;Goncalves, M;de Blic, J
通讯作者：
de Blic, J
影响因子：
2
作者：
Chen, Jiande;Ji, Fengjuan;Yuan, Shuhua
通讯作者：
Yuan, Shuhua
影响因子：
--
作者：
Li, Qing-Ling;Dong, He-Ting;Chen, Zheng-Rong
通讯作者：
Chen, Zheng-Rong
影响因子：
2.4
作者：
De Schutter I;Dreesman A;Soetens O;De Waele M;Crokaert F;Verhaegen J;Piérard D;Malfroot A
通讯作者：
Malfroot A
影响因子：
3.7
作者：
Sun H;Li S;Yan Y;Chen Z;Wang Y;Hao C;Ji W
通讯作者：
Ji W