Bisphosphonate-based nanocomposite hydrogels for biomedical applications
Bisphosphonate-based nanocomposite hydrogels for biomedical applications
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用于生物医学应用的双膦酸盐纳米复合水凝胶
DOI：
10.1016/j.bioactmat.2020.06.002
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发表时间：
2020-06
期刊：
影响因子：
--
通讯作者：
Bian Liming
中科院分区：
文献类型：
--
作者：
Yuan Weihao;Li Zhuo;Xie Xian;Zhang Zhi-Yong;Bian Liming
Nanocomposite hydrogels consist of polymeric network embedded with functional nanoparticles or nanostructures, which not only contribute to the enhanced mechanical properties but also exhibit the bioactivities for regulating cell behavior. Bisphosphonates (BPs) are capable of coordinating with various metal ions and modulating bone homeostasis. Thanks to the inherent dynamic properties of metal–ligand coordination bonds, BP-based nanocomposite hydrogels possess tunable mechanical properties, highly dynamic structures, and the capability to mediate controlled release of encapsulated therapeutic agents, thereby making them highly versatile for various biomedical applications. This review presents the comprehensive overview of recent developments in BP-based nanocomposite hydrogels with an emphasis on the properties of embedded nanoparticles (NPs) and interactions between hydrogel network and NPs. Furthermore, various challenges in the biomedical applications of these hydrogels are discussed to provide an outlook of potential clinical translation.
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影响因子：
16.1
作者：
Chacko RT;Ventura J;Zhuang J;Thayumanavan S
通讯作者：
Thayumanavan S
DOI：
--
发表时间：
1996-08
期刊：
Arzneimittel-Forschung
影响因子：
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