Bacillus thuringiensis: A story of a successful bioinsecticide.
Bacillus thuringiensis: A story of a successful bioinsecticide.
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DOI：
10.1016/j.ibmb.2011.02.006
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发表时间：
2011-07
影响因子：
3.8
通讯作者：
Soberon, Mario
中科院分区：
文献类型：
--
作者：
Bravo, Alejandra;Likitvivatanavong, Supaporn;Gill, Sarjeet S.;Soberon, Mario
苏云金芽孢杆菌（Bt）细菌是昆虫病原体，其依赖于被称为Cry和Cyt毒素的杀虫成孔蛋白来杀死其昆虫幼虫宿主。至少四种不同的非结构相关蛋白质家族形成毒素的Cry毒素组。某些Cry毒素在转基因作物中的表达有助于有效控制昆虫害虫，从而显著减少化学杀虫剂的使用。三结构域Cry毒素家族的作用模式涉及这些毒素与几种昆虫中肠蛋白的顺序相互作用，促进前孔寡聚体结构的形成和随后的膜插入，这导致通过渗透压休克杀死中肠昆虫细胞。在这篇手稿中，我们回顾了最近的进展，了解该家族的蛋白质在鳞翅目，双翅目和鞘翅目昆虫的行动方式。有趣的是，类似的Cry结合蛋白已被确定在三个昆虫订单，钙粘蛋白，氨肽酶-N和碱性磷酸酶，这表明一个保守的行动模式。此外，最近的数据昆虫响应哭毒素攻击进行了讨论。最后，我们回顾了目前农业中使用的不同Bt产品，包括转基因作物。
Bacillus thuringiensis (Bt) bacteria are insect pathogens that rely on insecticidal pore forming proteins known as Cry and Cyt toxins to kill their insect larval hosts. At least four different non-structurally related families of proteins form the Cry toxin group of toxins. The expression of certain Cry toxins in transgenic crops has contributed to an efficient control of insect pests resulting in a significant reduction in chemical insecticide use. The mode of action of the three domain Cry toxin family involves sequential interaction of these toxins with several insect midgut proteins facilitating the formation of a pre-pore oligomer structure and subsequent membrane insertion that leads to the killing of midgut insect cells by osmotic shock. In this manuscript we review recent progress in understanding the mode of action of this family of proteins in lepidopteran, dipteran and coleopteran insects. Interestingly, similar Cry-binding proteins have been identified in the three insect orders, as cadherin, aminopeptidase-N and alkaline phosphatase suggesting a conserved mode of action. Also, recent data on insect responses to Cry toxin attack is discussed. Finally, we review the different Bt based products, including transgenic crops, that are currently used in agriculture.
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影响因子：
3.8
作者：
Chen, Jianwu;Aimanova, Karlygash G.;Pan, Songqin;Gill, Sarjeet S.
通讯作者：
Gill, Sarjeet S.
影响因子：
3.8
作者：
Cancino-Rodezno, Angeles;Alexander, Cynthia;Villasenor, Roberto;Pacheco, Sabino;Porta, Helena;Pauchet, Yannick;Soberon, Mario;Gill, Sarjeet S.;Bravo, Alejandra
通讯作者：
Bravo, Alejandra
影响因子：
6.7
作者：
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通讯作者：
Aroian RV
影响因子：
4.8
作者：
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通讯作者：
Jurat-Fuentes, Juan Luis
影响因子：
3.2
作者：
Boonserm, P;Mo, M;Lescar, J
通讯作者：
Lescar, J