Optophysiological analysis of associational circuits in the olfactory cortex.

Optophysiological analysis of associational circuits in the olfactory cortex.
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DOI:
10.3389/fncir.2012.00018
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发表时间:
2012
影响因子:
3.5
通讯作者:
Murthy VN
Murthy VN
中科院分区:
医学3区
文献类型:
--
作者:
Hagiwara A;Pal SK;Sato TF;Wienisch M;Murthy VN

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初级嗅觉皮质区直接接收来自嗅球的输入,但也具有广泛的联合连接,这些连接主要通过经典解剖学方法进行研究。在此,我们利用光生理学方法阐明了前梨状皮质和后梨状皮质(aPC和pPC)中联合连接的功能特性。我们发现,aPC接收来自前嗅核(AON)的密集功能连接,AON是嗅觉皮质回路中的一个主要枢纽。aPC内长期在皮质自联想模型中被提及的局部递归连接是稀疏且微弱的。相比之下,pPC接收来自AON的可忽略不计的输入,但与aPC有密集连接,并且比aPC具有更多的局部递归连接。最后,从pPC到aPC的功能连接可忽略不计。我们的研究为aPC在气味处理中更具感觉作用以及pPC具有联想作用提供了回路基础。
Primary olfactory cortical areas receive direct input from the olfactory bulb, but also have extensive associational connections that have been mainly studied with classical anatomical methods. Here, we shed light on the functional properties of associational connections in the anterior and posterior piriform cortices (aPC and pPC) using optophysiological methods. We found that the aPC receives dense functional connections from the anterior olfactory nucleus (AON), a major hub in olfactory cortical circuits. The local recurrent connectivity within the aPC, long invoked in cortical autoassociative models, is sparse and weak. By contrast, the pPC receives negligible input from the AON, but has dense connections from the aPC as well as more local recurrent connections than the aPC. Finally, there are negligible functional connections from the pPC to aPC. Our study provides a circuit basis for a more sensory role for the aPC in odor processing and an associative role for the pPC.
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