Use of the Renal Angina Index in Determining Acute Kidney Injury.
Use of the Renal Angina Index in Determining Acute Kidney Injury.
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DOI：
10.1016/j.ekir.2018.01.013
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发表时间：
2018-05
影响因子：
6
通讯作者：
Noiri E
中科院分区：
文献类型：
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作者：
Matsuura R;Srisawat N;Claure-Del Granado R;Doi K;Yoshida T;Nangaku M;Noiri E
肾性心绞痛指数（RAI）是根据患者的肌酐和病情评分的变化确定的。本研究的目的是评估RAI在预测亚洲重症监护病房（ICU）患者持续性急性肾损伤（阿基）方面的有效性。这是对在日本和泰国进行的3项前瞻性研究的亚组分析。使用Goldstein及其同事的方法计算所有入组患者的RAI，并对第2天的成人进行微小修改。为了进一步确定RAI的准确性，我们评估了一个亚组的患者，他们在ICU入院时的基线血清肌酐值是可用的（即，医院获得性阿基患者）。评估阿基生物标志物在改善RAI性能方面的功效。结局定义为48小时内阿基2或3期。在分析的263例患者中，共有22例在48小时内进展为2期或3期阿基。在接受者操作特征分析中，RAI与0.63的曲线下面积（AUC）相关，截止值为10。在那些从普通病房入院的患者中，RAI表现良好，AUC为0.73，临界值为6。L型脂肪酸结合蛋白与RAI的组合改善了评估持续性阿基的预测性能，AUC为0.79。RAI可有效预测从普通病房收治的成人患者的持续性阿基。将阿基生物标志物并入RAI可能会改善预测。
The renal angina index (RAI) is determined based on changes in the creatinine and condition scores of patients. The aim of this study is to evaluate the efficacy of the RAI in predicting persistent acute kidney injury (AKI) in Asian intensive care unit (ICU) patients. This is a subanalysis of 3 prospective studies conducted in Japan and Thailand. The RAI was calculated for all enrolled patients using the method of Goldstein and colleagues, with a minor modification for adults on day 2. To determine the accuracy of RAI further, we evaluated a subgroup of patients for whom baseline serum creatinine values were available at ICU admission (i.e., those with hospital-acquired AKI). AKI biomarkers were evaluated for their efficacy in improving the performance of RAI. The outcome was defined as AKI stage 2 or 3 over 48 hours. Of the 263 patients analyzed, a total of 22 progressed to stage 2 or 3 AKI over 48 hours. The RAI was associated with an area under the curve (AUC) of 0.63 in receiver-operating characteristics analysis, with a cutoff of 10. In those admitted from general wards, the RAI had good performance, with an AUC of 0.73 and a cutoff of 6. A combination of L-type fatty acid–binding protein with the RAI improved the predictive performance for assessing persistent AKI with an AUC of 0.79. The RAI may be effective in predicting persistent AKI in adult patients admitted from general wards. Incorporation of AKI biomarkers into the RAI may potentially improve prediction.
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DOI：
10.1093/ndt/gfu292
发表时间：
2014-11
期刊：
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子：
--
作者：
Hoste EA;McCullough PA;Kashani K;Chawla LS;Joannidis M;Shaw AD;Feldkamp T;Uettwiller-Geiger DL;McCarthy P;Shi J;Walker MG;Kellum JA;Sapphire Investigators
通讯作者：
Sapphire Investigators
DOI：
10.2215/cjn.00710113
发表时间：
2013-09-06
影响因子：
9.8
作者：
Susantitaphong, Paweena;Cruz, Dinna N.;Jaber, Bertrand L.
通讯作者：
Jaber, Bertrand L.
DOI：
10.2215/cjn.05190513
发表时间：
2014-04-07
影响因子：
9.8
作者：
Cruz, Dinna N.;Ferrer-Nadal, Asuncion;Ronco, Claudio
通讯作者：
Ronco, Claudio
影响因子：
38.9
作者：
Flechet, Marine;Guiza, Fabian;Meyfroidt, Geert
通讯作者：
Meyfroidt, Geert
影响因子：
19.6
作者：
通讯作者：
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