Coronary microcirculation changes in non-ischemic dilated cardiomyopathy identified by novel perfusion CT.
Coronary microcirculation changes in non-ischemic dilated cardiomyopathy identified by novel perfusion CT.
复制标题
DOI：
10.1007/s10554-015-0619-9
复制
发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
Ritman EL
中科院分区：
文献类型：
--
作者：
Miller WL;Behrenbeck TR;McCollough CH;Williamson EE;Leng S;Kline TL;Ritman EL
心肌内微血管显示心肌病的功能变化。然而，临床计算机断层扫描（CT）没有足够的空间分辨率来评估微血管。我们的假设是，这些功能的变化表现为改变小动脉灌注领土的空间分布的异质性。我们的目标是确定灌注CT的空间分析是否可以在临床上检测到非缺血性扩张型心肌病（DCM）的心肌内微循环的功能和结构的变化。研究了两组：（1）对照组（12名男性和12名女性），无危险因素，也无冠状动脉疾病证据;（2）DCM组（12名男性和12名女性），左心室射血分数≤ 40%，无冠状动脉疾病证据。使用CT扫描，测量LV游离壁厚度和曲率半径。DCM组分为游离壁厚度<11.5mm和≥ 11.5mm两组，在心肌显像期测量心肌灌注（F）和心肌血容量（Bv）。两组间总体心肌F或Bv无显著差异。然而，与对照组相比，DCM组的心肌区域数据显示空间异质性显著增加。研究结果表明，改变功能的亚分辨率心肌内微循环可以量化与心肌灌注CT和显着的变化，这些参数发生在DCM受试者与LV壁厚度大于11.5毫米。
Intramyocardial microvessels demonstrate functional changes in cardiomyopathies. However, clinical computed tomography (CT) does not have adequate spatial resolution to assess the microvessels. Our hypothesis is that these functional changes manifest as altered heterogeneity of the spatial distribution of arteriolar perfusion territories. Our goal was to determine whether the spatial analysis of perfusion CT could clinically detect changes in the function and structure of the intramyocardial microcirculation in a non-ischemic dilated cardiomyopathy (DCM). Two groups were studied: (1) a Control group (12 male plus 12 female) with no risk factors nor evidence of coronary artery disease, and (2) a DCM group (12 male plus 12 female)with left ventricular ejection fraction ≤40 %and no evidence of coronary artery disease. Using the CT scan, the LV free wall thickness and its radius of curvature were measured. The DCM group was sub divided into those with LV free wall thickness <11.5 mm and those with thickness≥11.5 mm. In themyocardial opacification phase of the CT scan sequence, myocardial perfusion (F) and intramyocardial blood volume (Bv) for multiple intramyocardial regions were computed. No significant differences between the groups were demonstrable in overall myocardial F or Bv. However, the myocardial regional data showed significantly increased spatial heterogeneity in the DCM group when compared to the Control group. The findings demonstrate that altered function of the subresolution intramyocardial microcirculation can be quantified with myocardial perfusion CT and that significant changes in these parameters occur in the DCM subjects with LV wall thickness greater than 11.5 mm.
登录
查看更多内容
影响因子：
5.7
作者：
Spoladore, R.;Fisicaro, A.;Camici, P. G.
通讯作者：
Camici, P. G.
DOI：
10.1016/0735-1097(90)90282-t
发表时间：
1990-03-15
影响因子：
24
作者：
AGATSTON, AS;JANOWITZ, WR;DETRANO, R
通讯作者：
DETRANO, R
DOI：
10.1177/1074248406292574
发表时间：
2006-09-01
影响因子：
2.6
作者：
Bitar, Fahed;Lerman, Amir;Elkayam, Uri
通讯作者：
Elkayam, Uri
影响因子：
39.3
作者：
Ugander, Martin;Oki, Abiola J.;Arai, Andrew E.
通讯作者：
Arai, Andrew E.
影响因子：
37.8
作者：
Neglia, D;Michelassi, C;Parodi, O
通讯作者：
Parodi, O