Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia.
Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia.
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DOI：
10.1176/appi.ajp.2012.12020186
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发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Braff DL
中科院分区：
文献类型：
--
作者：
Greenwood TA;Swerdlow NR;Gur RE;Cadenhead KS;Calkins ME;Dobie DJ;Freedman R;Green MF;Gur RC;Lazzeroni LC;Nuechterlein KH;Olincy A;Radant AD;Ray A;Schork NJ;Seidman LJ;Siever LJ;Silverman JM;Stone WS;Sugar CA;Tsuang DW;Tsuang MT;Turetsky BI;Light GA;Braff DL
The Consortium on the Genetics of Schizophrenia has undertaken a large multisite study to characterize 12 neurophysiological and neurocognitive endophenotypic measures as a step toward understanding the complex genetic basis of schizophrenia. The authors previously demonstrated the heritability of these endophenotypes; in the present study, genetic linkage was evaluated. Each family consisted of a proband with schizophrenia, at least one unaffected sibling, and both parents. A total of 1,286 participants from 296 families were genotyped in two phases, and 1,004 individuals were also assessed for the endophenotypes. Linkage analyses of the 6,055 single-nucleotide polymorphisms that were successfully assayed, 5,760 of which were common to both phases, were conducted using both variance components and pedigree-wide regression methods. Linkage analyses of the 12 endophenotypes collectively identified one region meeting genome-wide significance criteria, with a LOD (log of odds) score of 4.0 on chromosome 3p14 for the antisaccade task, and another region on 1p36 nearly meeting genome-wide significance, with a LOD score of 3.5 for emotion recognition. Chromosomal regions meeting genome-wide suggestive criteria with LOD scores >2.2 were identified for spatial processing (2p25 and 16q23), sensorimotor dexterity (2q24 and 2q32), prepulse inhibition (5p15), the California Verbal Learning Test (8q24), the degraded-stimulus Continuous Performance Test (10q26), face memory (10q26 and 12p12), and the Letter-Number Span (14q23). Twelve regions meeting genome-wide significant and suggestive criteria for previously identified heritable, schizophrenia-related endophenotypes were observed, and several genes of potential neurobiological interest were identified. Replication and further genomic studies are needed to assess the biological significance of these results.
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影响因子：
4.5
作者：
Anokhin, Andrey P.;Vedeniapin, Andrei B.;Boutros, Nashaat N.
通讯作者：
Boutros, Nashaat N.
影响因子：
2.1
作者：
Blangero, J;Williams, JT;Almasy, L
通讯作者：
Almasy, L
影响因子：
6.6
作者：
Calkins, Monica E.;Dobie, Dorcas J.;Braff, David L.
通讯作者：
Braff, David L.
影响因子：
30.8
作者：
Abecasis, GR;Cherny, SS;Cardon, LR
通讯作者：
Cardon, LR
影响因子：
11
作者：
Badner, JA;Gershon, ES
通讯作者：
Gershon, ES