An efficient rectangular optimization method for sparse orthogonal collimator based small animal irradiation.
An efficient rectangular optimization method for sparse orthogonal collimator based small animal irradiation.
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DOI：
10.1088/1361-6560/ac910b
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发表时间：
2022-09-28
影响因子：
3.5
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中科院分区：
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临床放射疗法被广泛用于临床放射疗法，以临床翻译的测试领域来处理不同的恶性肿瘤，需要模仿人类放射疗法的临床动物实验。
基于直接的矩形孔径优化（RAO）的稀疏正交准直仪（SOC）基本上简化了小型化的硬件。而是小矩阵剂量加载物的Kronecker产品使用快速的迭代收缩率算法（FISTA）进一步加速了优化问题。
在本研究中包括四个小鼠病例，包括肝脏，脑肿瘤，凹入的u-Target（TMI）病例（TMI）病例，其中包括手动划定的目标和七个Coplanar field Soc Imrt（SIMRT）。计划目标量（PTV）统计范围在TMI案例的1％以内，SIMRT计划在降低了PTV，肾脏，肺，心脏和肠的热点（也称为DMAX），分别是20.5％，24.67％，20.13％和17.8％的情况， RT轻轻升高R50，整体剂量增加了2.23％，并且2.78％。
显着改进的SIMRT优化方法允许在1分钟内为较小的目标创建快速计划，并使复杂的TMI规划可行，同时通过具有通力图优化的理想主义IMRT实现可比的剂量学。
Intensity-modulated radiotherapy (IMRT) is widely used in clinical radiotherapy, treating varying malignancies with conformal doses. As the test field for clinical translation, preclinical small animal experiments need to mimic the human radiotherapy condition, including IMRT. However, small animal IMRT is a systematic challenge due to the lack of corresponding hardware and software for miniaturized targets. The sparse orthogonal collimators (SOC) based on the direct rectangular aperture optimization (RAO) substantially simplified the hardware for miniaturization. This study investigates and evaluates a significantly improved RAO algorithm for complex mouse irradiation using SOC. Because the Kronecker product representation of the rectangular aperture is the main limitation of the computational performance, we reformulated matrix multiplication in the data fidelity term using multiplication with small matrices instead of the Kronecker product of the dose loading matrices. Solving the optimization problem was further accelerated using the Fast Iterative Shrinkage-Thresholding Algorithm (FISTA). Four mouse cases, including a liver, a brain tumor, a concave U-target, and a complex total marrow irradiation (TMI) case, were included in this study with manually delineated targets and OARs. Seven coplanar-field SOC IMRT (sIMRT) plans were compared with idealistic fluence map based IMRT (iIMRT) plans. For the first three cases with simpler and smaller targets, the differences between sIMRT plans and iIMRT plans in the planning target volumes (PTV) statistics are within 1%. For the TMI case, the sIMRT plans are superior in reducing hot spots (also termed Dmax) of PTV, kidneys, lungs, heart, and bowel by 20.5%, 31.5%, 24.67%, 20.13%, and 17.78%, respectively. On average, in four cases in this study, the sIMRT plan conformity is comparable to that of the iIMRT’s with lightly increased R50 and Integral Dose by 2.23% and 2.78%. The significantly improved sIMRT optimization method allows fast plan creation in under 1 minute for smaller targets and makes complex TMI planning feasible while achieving comparable dosimetry to idealistic IMRT with fluence map optimization.
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影响因子：
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