Feasibility of a dietary intervention to modify gut microbial metabolism in patients with hematopoietic stem cell transplantation.
Feasibility of a dietary intervention to modify gut microbial metabolism in patients with hematopoietic stem cell transplantation.
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DOI：
10.1038/s41591-023-02587-y
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发表时间：
2023-11
期刊：
影响因子：
82.9
通讯作者：
Reddy, Pavan
中科院分区：
文献类型：
--
作者：
Riwes, Mary M.;Golob, Jonathan L.;Magenau, John;Shan, Mengrou;Dick, Gregory;Braun, Thomas;Schmidt, Thomas M.;Pawarode, Attaphol;Anand, Sarah;Ghosh, Monalisa;Maciejewski, John;King, Darren;Choi, Sung;Yanik, Gregory;Geer, Marcus;Hillman, Ethan;Lyssiotis, Costas A.;Tewari, Muneesh;Reddy, Pavan
Evaluation of the impact of dietary intervention on gastrointestinal microbiota and metabolites after allogeneic hematopoietic stem cell transplantation (HCT) is lacking. We conducted a feasibility study as the first of a two-phase trial. Ten adults received resistant potato starch (RPS) daily from day −7 to day 100. The primary objective was to test the feasibility of RPS and its effect on intestinal microbiome and metabolites, including the short-chain fatty acid butyrate. Feasibility met the preset goal of 60% or more, adhering to 70% or more doses; fecal butyrate levels were significantly higher when participants were on RPS than when they were not (P < 0.0001). An exploratory objective was to evaluate plasma metabolites. We observed longitudinal changes in plasma metabolites compared to baseline, which were independent of RPS (P < 0.0001). However, in recipients of RPS, the dominant plasma metabolites were more stable compared to historical controls with significant difference at engraftment (P < 0.05). These results indicate that RPS in recipients of allogeneic HCT is feasible; in this study, it was associated with significant alterations in intestinal and plasma metabolites. A phase 2 trial examining the effect of RPS on graft-versus-host disease in recipients of allogeneic HCT is underway. ClinicalTrials.gov registration: NCT02763033. In a pilot feasibility study involving recipients of allogeneic hematopoietic stem cell transplants, adherence to a dietary intervention and its effects on the gut microbiota were assessed in the run-in to a study testing the effects of modulation of the microbiome on transplant outcomes.
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DOI：
10.1016/j.bbmt.2014.01.030
发表时间：
2014-05
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Holler E;Butzhammer P;Schmid K;Hundsrucker C;Koestler J;Peter K;Zhu W;Sporrer D;Hehlgans T;Kreutz M;Holler B;Wolff D;Edinger M;Andreesen R;Levine JE;Ferrara JL;Gessner A;Spang R;Oefner PJ
通讯作者：
Oefner PJ
影响因子：
30.5
作者：
Mathewson ND;Jenq R;Mathew AV;Koenigsknecht M;Hanash A;Toubai T;Oravecz-Wilson K;Wu SR;Sun Y;Rossi C;Fujiwara H;Byun J;Shono Y;Lindemans C;Calafiore M;Schmidt TM;Honda K;Young VB;Pennathur S;van den Brink M;Reddy P
通讯作者：
Reddy P
影响因子：
29
作者：
Donohoe DR;Garge N;Zhang X;Sun W;O'Connell TM;Bunger MK;Bultman SJ
通讯作者：
Bultman SJ
DOI：
10.1084/jem.20112408
发表时间：
2012-05-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Jenq RR;Ubeda C;Taur Y;Menezes CC;Khanin R;Dudakov JA;Liu C;West ML;Singer NV;Equinda MJ;Gobourne A;Lipuma L;Young LF;Smith OM;Ghosh A;Hanash AM;Goldberg JD;Aoyama K;Blazar BR;Pamer EG;van den Brink MR
通讯作者：
van den Brink MR
影响因子：
7.6
作者：
Casellas, F.;Borruel, N.;Malagelada, J. -R.
通讯作者：
Malagelada, J. -R.