Co-expression of LASS2 and TGF-β1 predicts poor prognosis in hepatocellular carcinoma.
Co-expression of LASS2 and TGF-β1 predicts poor prognosis in hepatocellular carcinoma.
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LASS2 和 TGF-β1 的共表达预测肝细胞癌的不良预后
DOI：
10.1038/srep32421
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发表时间：
2016-09-01
影响因子：
4.6
通讯作者：
Jin H
中科院分区：
文献类型：
--
作者：
Ruan H;Wang T;Yang C;Jin G;Gu D;Deng X;Wang C;Qin W;Jin H
酵母LAG1的长寿保证同源物2(LASS2)已被报道在人类癌症的发生发展中发挥重要的肿瘤抑制作用。然而，LASS2在肝细胞癌中的预后价值却鲜为人知。在本研究中，我们分析了LASS_2和转化生长因子-β-1水平之间的相关性，并评估了它们在肝细胞癌患者中的预后价值。我们首先用免疫组织化学方法分析了LASS2和转化生长因子-β-1在两个独立的队列中的表达。Kaplan-Meier生存分析和Cox回归分析评估肝细胞癌的预后。LASS_2和转化生长因子-β_1低表达的肝细胞癌患者的总生存期和复发时间明显短于高表达的肝细胞癌患者。LASS_2和转化生长因子-β_1的联合表达是肝细胞癌发生OS和复发的独立危险因素。结论：LASS_2和转化生长因子-β_1的低表达与肝细胞癌的侵袭性和预后不良有关，可作为判断肝细胞癌预后的一种新的生物标志物。
Longevity assurance homolog 2 of yeast LAG1 (LASS2) has been reported to act as an important tumor suppressor in the development of human cancers. However, little is known about the prognostic value of LASS2 in hepatocellular carcinoma (HCC) . In the present study, we analyzed correlation between LASS2 and TGF-β1 levels, and evaluated their prognostic values in HCC patients. We first analyzed the expression of LASS2 and TGF-β1 in two independent cohorts (test cohort: 184 HCC patients; validation cohort: 118 HCC patients) using immunohistochemistry (IHC). Kaplan-Meier survival and Cox regression analyses were executed to evaluate the prognosis of HCC. The results of IHC analysis revealed a positive correlation between the expression of LASS2 and TGF-β1. HCC Patients with low expression of LASS2 and TGF-β1 had shorter overall survival (OS) and time to recurrence (TTR) than patients with high expression of LASS2 and TGF-β1. Furthermore, combination of LASS2 and TGF-β1 was an independent and significant risk factor for OS and TTR. In conclusion, low expression of LASS2 and TGF-β1 contributes to the aggressiveness and poor prognosis of HCC, and may represent a novel prognostic biomarker for HCC patients.
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影响因子：
13.5
作者：
Senturk, Serif;Mumcuoglu, Mine;Ozturk, Mehmet
通讯作者：
Ozturk, Mehmet
影响因子：
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影响因子：
11.2
作者：
Forrester, E;Chytil, A;Moses, HL
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