Mesenchymal stem cells as therapeutics.
Mesenchymal stem cells as therapeutics.
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DOI：
10.1146/annurev-bioeng-070909-105309
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发表时间：
2010-08-15
影响因子：
9.7
通讯作者：
Milwid JM
中科院分区：
文献类型：
--
作者：
Parekkadan B;Milwid JM
间充质干细胞（MSC）是一种多能细胞，临床上正在探索作为治疗各种免疫介导疾病的新疗法。最初被认为是骨骼组织修复的再生疗法，最近已显示MSC可调节内源性组织和免疫细胞。作用机制的临床前研究表明，MSC移植提供的治疗效果是短暂的，与MSC和宿主细胞之间的动态旁分泌相互作用有关。因此，将MSC表示为载药颗粒可以允许药代动力学模型预测MSC移植物的治疗活性作为药物递送模式的函数。通过整合MSC生物学、治疗和工程学的原理，该领域将迎来下一代干细胞治疗。
Mesenchymal stem cells (MSCs) are multipotent cells that are being clinically explored as a new therapeutic for treating a variety of immune-mediated diseases. First heralded as a regenerative therapy for skeletal tissue repair, MSCs have recently been shown to modulate endogenous tissue and immune cells. Preclinical studies of the mechanism of action suggest that the therapeutic effects afforded by MSC transplantation are short-lived and related to dynamic, paracrine interactions between MSCs and host cells. Therefore, representations of MSCs as drug-loaded particles may allow for pharmacokinetic models to predict the therapeutic activity of MSC transplants as a function of drug delivery mode. By integrating principles of MSC biology, therapy, and engineering, the field is armed to usher in the next generation of stem cell therapeutics.
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