Bordetella pertussis infection or vaccination substantially protects mice against B. bronchiseptica infection.
Bordetella pertussis infection or vaccination substantially protects mice against B. bronchiseptica infection.
复制标题
百日草感染或疫苗接种可防止小鼠免受支气管杆菌感染的影响。
DOI：
10.1371/journal.pone.0006778
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发表时间：
2009-08-26
期刊：
影响因子：
3.7
通讯作者：
Harvill ET
中科院分区：
文献类型：
--
作者：
Goebel EM;Zhang X;Harvill ET
虽然B.支气管败血症有效地感染广泛的哺乳动物宿主，并在它们之间有效地传播，但很少在人类中观察到。与B的许多其他宿主相反。在支气管败血症中，人类是明显特化的病原体B的宿主。百日咳，绝大多数人因接种疫苗、感染或两者兼而有之而具有免疫力。在这里我们探讨是否免疫B。百日咳可以预防B。支气管败血症感染在鼠模型中，感染或接种B.百日咳诱导的抗体识别B抗原。支气管败血症和保护小鼠的下呼吸道免受三种遗传学上不同的B菌株的侵害。支气管败血症，有效地感染幼稚动物。此外，用纯化的B.百日咳衍生的百日咳毒素、丝状血凝素或人无细胞疫苗Adacel对B具有类似的保护作用。支气管败血症攻毒。这些数据表明个体对B.百日咳影响B型B。支气管败血症感染，并建议对B.人类的百日咳可以解释观察到的B缺乏。支气管炎传播。这也可以解释B的明显关联。支气管败血症感染与免疫功能低下的状态。
Although B. bronchiseptica efficiently infects a wide range of mammalian hosts and efficiently spreads among them, it is rarely observed in humans. In contrast to the many other hosts of B. bronchiseptica, humans are host to the apparently specialized pathogen B. pertussis, the great majority having immunity due to vaccination, infection or both. Here we explore whether immunity to B. pertussis protects against B. bronchiseptica infection. In a murine model, either infection or vaccination with B. pertussis induced antibodies that recognized antigens of B. bronchiseptica and protected the lower respiratory tract of mice against three phylogenetically disparate strains of B. bronchiseptica that efficiently infect naïve animals. Furthermore, vaccination with purified B. pertussis-derived pertactin, filamentous hemagglutinin or the human acellular vaccine, Adacel, conferred similar protection against B. bronchiseptica challenge. These data indicate that individual immunity to B. pertussis affects B. bronchiseptica infection, and suggest that the high levels of herd immunity against B. pertussis in humans could explain the lack of observed B. bronchiseptica transmission. This could also explain the apparent association of B. bronchiseptica infections with an immunocompromised state.
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影响因子：
5.2
作者：
Liese, JG;Renner, C;Belohradsky, BH
通讯作者：
Belohradsky, BH
影响因子：
7.5
作者：
Bonhoeffer, J;Bär, G;Heininger, U
通讯作者：
Heininger, U
影响因子：
3.1
作者：
Harvill, ET;Cotter, PA;Miller, JF
通讯作者：
Miller, JF
影响因子：
9.4
作者：
Lorenzo-Pajuelo, B;Villanueva, JL;de Tejada, GM
通讯作者：
de Tejada, GM
影响因子：
9.4
作者：
GUEIRARD, P;WEBER, C;GUISO, N
通讯作者：
GUISO, N