Protein kinase activity associated with a phorbol ester receptor purified from mouse brain.
Protein kinase activity associated with a phorbol ester receptor purified from mouse brain.
复制标题
与从小鼠脑中纯化的佛波酯受体相关的蛋白激酶活性。
作者：
C. Ashendel;J. Staller;R. Boutwell
在纯化小鼠脑颗粒蛋白过程中，蛋白激酶活性与12-O-[3H]十四烷酰基磷酸-13-乙酸酯受体共增殖。所有试图从受体中分离蛋白激酶活性的尝试都失败了。分离的受体需要磷脂和二价钙才能获得最大的蛋白激酶活性。蛋白激酶不被环核苷酸或钙调蛋白激活。受体相关蛋白激酶活性与钙和磷脂依赖蛋白激酶之间存在惊人的相似之处，这被怀疑介导与磷脂酰肌醇转换增加相关的生物刺激效应。
Protein kinase activity copurified with the receptor for 12-O-[3H]tetradecanoylphorbol-13-acetate during its purification from mouse brain particulate protein. All attempts to resolve the protein kinase activity from the receptor were unsuccessful. The isolated receptor required phospholipid and divalent calcium for maximal protein kinase activity. The protein kinase was not activated by cyclic nucleotides or calmodulin. There are striking similarities between the receptor-associated protein kinase activity and the calcium- and phospholipid-dependent protein kinase, which has been suspected of mediating the effects of biological stimuli associated with increased phosphatidylinositol turnover.
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影响因子：
--
作者：
Diamond, L;O'Brien, T G;Baird, W M
通讯作者：
Baird, W M
GH4C1 大鼠垂体细胞对佛波酯的生物反应性与受体水平之间的关系。
影响因子：
11.2
作者：
Jaken,S;TashjianJr,AH;Blumberg,PM
通讯作者：
Blumberg,PM
DOI：
10.1016/0006-291x(81)91779-4
发表时间：
1981-01-01
影响因子：
3.1
作者：
ASHENDEL, CL;BOUTWELL, RK
通讯作者：
BOUTWELL, RK
鉴定小鼠组织可溶性部分中钙和磷脂依赖性佛波酯结合活性。
DOI：
10.1016/s0006-291x(83)80157-0
发表时间：
1983
影响因子：
3.1
作者：
Ashendel,CL;Staller,JM;Boutwell,RK
通讯作者：
Boutwell,RK
从小鼠大脑的颗粒蛋白部分中溶解、纯化和重建佛波酯受体。
影响因子：
11.2
作者：
Ashendel,CL;Staller,JM;Boutwell,RK
通讯作者：
Boutwell,RK