IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses.
IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses.
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DOI：
10.1016/j.immuni.2013.04.011
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发表时间：
2013-05-23
期刊：
影响因子：
32.4
通讯作者：
Ginhoux F
中科院分区：
文献类型：
--
作者：
Schlitzer A;McGovern N;Teo P;Zelante T;Atarashi K;Low D;Ho AW;See P;Shin A;Wasan PS;Hoeffel G;Malleret B;Heiseke A;Chew S;Jardine L;Purvis HA;Hilkens CM;Tam J;Poidinger M;Stanley ER;Krug AB;Renia L;Sivasankar B;Ng LG;Collin M;Ricciardi-Castagnoli P;Honda K;Haniffa M;Ginhoux F
小鼠和人类树突状细胞（dc）由功能特化的亚群组成，但物种间的精确相关性目前尚不完整。在这里，我们发现小鼠肺和肠固有层CD11b+ DC群体由两个亚群组成：FLT3和irf4依赖性CD24+CD64 - DC和污染csf - 1r依赖性CD24 - CD64+巨噬细胞。在功能上，CD24+CD11b+ dc的缺失在稳态和烟曲霉攻毒后破坏了CD4+ T细胞介导的白细胞介素-17 （IL-17）的产生。人CD1c+ dc，相当于小鼠CD24+CD11b+ dc，也表达IRF4，分泌IL-23，并促进T辅助17细胞反应。我们的数据揭示了小鼠CD11b+ DC区室的异质性，并鉴定了在小鼠和人的粘膜组织中表达irf4的DC专门指导IL-17反应。小鼠和人类DC亚群专门驱动IL-17反应的证明强调了物种间关键免疫功能的保护，并将促进小鼠体内研究结果的转化，以推进基于DC的临床治疗。粘膜CD11b+ dc由CD24+CD64−dc和CD24−CD64+巨噬细胞组成。粘膜CD24+CD11b+ dc依赖irf4， irf4依赖CD24+CD11b+ dc分泌IL-23α并控制粘膜IL-17反应。人CD1c+CD11b+ dc与小鼠CD24+CD11b+ dc功能同源
Mouse and human dendritic cells (DCs) are composed of functionally specialized subsets, but precise interspecies correlation is currently incomplete. Here, we showed that murine lung and gut lamina propria CD11b+ DC populations were comprised of two subsets: FLT3- and IRF4-dependent CD24+CD64− DCs and contaminating CSF-1R-dependent CD24−CD64+ macrophages. Functionally, loss of CD24+CD11b+ DCs abrogated CD4+ T cell-mediated interleukin-17 (IL-17) production in steady state and after Aspergillus fumigatus challenge. Human CD1c+ DCs, the equivalent of murine CD24+CD11b+ DCs, also expressed IRF4, secreted IL-23, and promoted T helper 17 cell responses. Our data revealed heterogeneity in the mouse CD11b+ DC compartment and identifed mucosal tissues IRF4-expressing DCs specialized in instructing IL-17 responses in both mouse and human. The demonstration of mouse and human DC subsets specialized in driving IL-17 responses highlights the conservation of key immune functions across species and will facilitate the translation of mouse in vivo findings to advance DC-based clinical therapies. Mucosal CD11b+ DCs consist of CD24+CD64− DCs and CD24−CD64+ macrophages Mucosal CD24+CD11b+ DCs are IRF4-dependent IRF4-dependent CD24+CD11b+ DCs secrete IL-23α and control mucosal IL-17 responses Human CD1c+CD11b+ DCs are functional homologs of murine CD24+CD11b+ DCs
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影响因子：
3.7
作者：
Chamilos G;Ganguly D;Lande R;Gregorio J;Meller S;Goldman WE;Gilliet M;Kontoyiannis DP
通讯作者：
Kontoyiannis DP
DOI：
10.1084/jem.20062648
发表时间：
2007-07-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Caton ML;Smith-Raska MR;Reizis B
通讯作者：
Reizis B
DOI：
10.4049/jimmunol.1102613
发表时间：
2012-10-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bajaña S;Roach K;Turner S;Paul J;Kovats S
通讯作者：
Kovats S
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
15.9
作者：
Bedoret, Denis;Wallemacq, Hugues;Bureau, Fabrice
通讯作者：
Bureau, Fabrice