A stepwise approach for functional near infrared spectroscopy measurement during natural bladder filling.
A stepwise approach for functional near infrared spectroscopy measurement during natural bladder filling.
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DOI：
10.21037/tau-23-275
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发表时间：
2023-10-31
影响因子：
2
通讯作者：
中科院分区：
文献类型：
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功能性近红外光谱（fNIRS）是一种多功能、无创、廉价的工具，可用于测量直立姿势填充物时膀胱感觉增加引起的脑皮质氧合血红蛋白（O2Hb）变化。本研究的目的是为fNIRS在诊断和治疗下尿路症状（包括膀胱过动症（OAB）和其他形式的下尿路功能障碍）方面的比较研究提供一个严格的方法学模板。没有任何泌尿系统疾病的参与者完成了有效的口服水化方案，促进和平衡膀胱自然填充。用感觉仪记录首次排尿欲望和实时膀胱感觉（0-100%）。24通道fNIRS模板同时记录前额皮质O2Hb。分析从“第一欲望”到100%感觉之间的每个通道，在本研究中定义为“高感觉”时期。通道按皮层区域细分为：右（9个通道）、左（9个通道）、中（6个通道）。共纳入8例受试者（男4例，女4例），平均年龄39±19.9岁，体重指数（BMI） 25±3.93 kg/m2。在年龄、体重指数、种族或基于生理性别的OAB调查得分方面没有差异。信号采集改进与充电宝的使用，姿态头部支持运动减少，和头帽优化。基于加速度的并发运动测量有效地去除运动伪影。O2Hb浓度模式在低感觉时不规则，在第一次欲望后的高感觉时增加。采用渐进式方法，本研究定义了膀胱充盈过程中改进前额叶近红外光谱信号采集和分析的方法指南。该技术表明，在正常受试者中，前额叶fNIRS皮层O2Hb随着膀胱感觉的升高而增加，并为OAB和其他形式的下尿路功能障碍患者的比较研究奠定了基础。
Functional near infrared spectroscopy (fNIRS) is a versatile, noninvasive, and inexpensive tool that can be used to measure oxyhemoglobin (O2Hb) changes in the cortical brain caused by increasing bladder sensation during filling in upright posture. This study’s purpose is to provide a rigorous methodologic template that can be implemented for comparative studies of fNIRS in the diagnosis and management of lower urinary tract symptoms including overactive bladder (OAB) and other forms of lower urinary tract dysfunction. Participants without any urologic conditions completed a validated oral hydration protocol facilitating and equilibrating natural bladder filling. First desire to void and real time bladder sensation (0–100%) were recorded using a Sensation Meter. A 24-channel fNIRS template simultaneously recorded prefrontal cortical O2Hb. Each channel was analyzed between “first desire” to void and 100% sensation, defined in this study as the period of “high sensation”. Channels were sub-divided by cortical regions: right (nine channels), left (nine channels), middle (six channels). A total of eight participants (male: n=4, female: n=4) were enrolled with mean age 39±19.9 years and body mass index (BMI) of 25±3.93 kg/m2. There were no differences in age, BMI, race, or OAB survey scores based on biological sex. Signal acquisition improved with power bank use, postural head support for motion reduction, and head cap optimization. Acceleration-based concurrent motion measurement was effectively utilized to remove motion artifacts. O2Hb concentration patterns appeared irregular during low sensation and increased during high sensation after first desire across the frontal cortex. Employing a stepwise approach, this study defined a methodological guide for improved prefrontal fNIRS signal acquisition and analysis during bladder filling. The technique demonstrated that prefrontal fNIRS cortical O2Hb increases with elevated bladder sensation in normal subjects and sets the stage for comparative studies in individuals with OAB and other forms of lower urinary tract dysfunction.
影响因子：
2
作者：
Naimi HA;Nagle AS;Vinod NN;Kolli H;Sheen D;De Wachter SG;Speich JE;Klausner AP
通讯作者：
Klausner AP