Mid-infrared spectroscopy of serum, a promising non-invasive method to assess prognosis in patients with ascites and cirrhosis.
Mid-infrared spectroscopy of serum, a promising non-invasive method to assess prognosis in patients with ascites and cirrhosis.
复制标题
DOI：
10.1371/journal.pone.0185997
复制
发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Bardou-Jacquet E
中科院分区：
文献类型：
--
作者：
Le Corvec M;Jezequel C;Monbet V;Fatih N;Charpentier F;Tariel H;Boussard-Plédel C;Bureau B;Loréal O;Sire O;Bardou-Jacquet E
预后检查在肝硬化和腹水患者的管理中至关重要。生物测试或分数在这种情况下表现不佳。中红外光纤倏逝波光谱法（MIR-FEWS）允许进行全球血清代谢分析，可通过测量血清中更广泛的代谢参数提供更多相关信息。在这里，我们提出了一个MIR-FEWS为基础的预测模型的准确性预测腹水和肝硬化患者的6个月生存期。前瞻性纳入腹水患者，随访6个月。在血清样品中测量MIR-FEWS光谱。利用FADA算法对MIR-FEWS获得的光谱变量进行筛选，并建立MIR模型。通过ROC曲线和90%/10%Monte Carlo交叉验证评估该模型的准确性。将6个月生存期的MIR模型准确性与Child-Pugh和MELD评分进行比较。纳入了119例患者。平均年龄为57.36±13.70岁，MELD评分为16.32±6.26，Child-Pugh评分为9.5±1.83。随访期间，23例患者死亡（20%）。MIR模型的6个月死亡率AUROC为0.90（CI 95：0.88-0.91），MELD为0.77（CI 95：0.66-0.89），Child-Pugh为0.76（CI 95：0.66-0.88）。MELD和Child-Pugh AUROC显著低于MIR模型（分别为p = 0.02和p = 0.02）。多变量logistic回归分析显示，MELD（p<0.05，OR：0.86; CI 95：0.76-0.97）、β受体阻滞剂（p = 0.036;OR：0.20; CI 95：0.04-0.90）和MIR模型（p<0.001; OR：0.50; CI 95：0.37-0.66）与6个月死亡率显著相关。在这项初步研究中，MIR-FEWS比MELD或Child-Pugh评分更准确地评估腹水和肝硬化患者的6个月预后。这些有希望的结果，如果得到更大规模研究的证实，表明中红外光谱可能有助于这些患者的管理。
Prognostic tests are critical in the management of patients with cirrhosis and ascites. Biological tests or scores perform poorly in that situation. Mid-infrared fibre evanescent wave spectroscopy (MIR-FEWS) which allows for global serum metabolic profiling may provide more relevant information by measuring a wider range of metabolic parameters in serum. Here we present the accuracy of a MIR-FEWS based predictive model for the prognosis of 6 months survival in patients with ascites and cirrhosis. Patients with ascites were prospectively included and followed up for 6 months. MIR-FEWS spectra were measured in serum samples. The most informative spectral variables obtained by MIR-FEWS were selected by FADA algorithm and then used to build the MIR model. Accuracy of this model was assessed by ROC curves and 90%/10% Monte Carlo cross-validation. MIR model accuracy for 6 months survival was compared to that of the Child-Pugh and MELD scores. 119 patients were included. The mean age was 57.36±13.70, the MELD score was 16.32±6.26, and the Child-Pugh score was 9.5±1.83. During follow-up, 23 patients died (20%). The MIR model had an AUROC for 6 months mortality of 0.90 (CI95: 0.88–0.91), the MELD 0.77 (CI95: 0.66–0.89) and Child-Pugh 0.76 (CI95: 0.66–0.88). MELD and Child-Pugh AUROCs were significantly lower than that of the MIR model (p = 0.02 and p = 0.02 respectively). Multivariate logistic regression analysis showed that MELD (p<0.05, OR:0.86;CI95:0.76–0.97), Beta blockers (p = 0.036;OR:0.20;CI95:0.04–0.90), and the MIR model (p<0.001; OR:0.50; CI95:0.37–0.66), were significantly associated with 6 months mortality. In this pilot study MIR-FEWS more accurately assess the 6-month prognosis of patients with ascites and cirrhosis than the MELD or Child-Pugh scores. These promising results, if confirmed by a larger study, suggest that mid infrared spectroscopy could be helpful in the management of these patients.
登录
查看更多内容
影响因子：
4.1
作者：
Hinson, JA;Pike, SL;Mayeux, PR
通讯作者：
Mayeux, PR
影响因子：
3.5
作者：
Keirsse, Julie;Lahaye, Elodie;Sire, Olivier
通讯作者：
Sire, Olivier
影响因子：
2.5
作者：
Backhaus, Juergen;Mueller, Ralf;Bugert, Peter
通讯作者：
Bugert, Peter
DOI：
10.3390/molecules18055373
发表时间：
2013-05-10
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Cui S;Chahal R;Boussard-Plédel C;Nazabal V;Doualan JL;Troles J;Lucas J;Bureau B
通讯作者：
Bureau B
影响因子：
13.5
作者：
Kamath, PS;Wiesner, RH;Kim, WR
通讯作者：
Kim, WR