Randomized controlled trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma.
Randomized controlled trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma.
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作者：
Meng Z;Garcia MK;Hu C;Chiang J;Chambers M;Rosenthal DI;Peng H;Zhang Y;Zhao Q;Zhao G;Liu L;Spelman A;Palmer JL;Wei Q;Cohen L
头颈部放射治疗后口腔干燥（口干）是癌症患者的常见问题，现有的治疗方法几乎没有益处。本试验的目的是确定针灸是否可以预防接受放射治疗的头颈部患者的口干症。在鼻咽癌患者中进行了一项随机对照试验，比较针灸和标准治疗。参与者在中国上海复旦大学上海肿瘤中心接受治疗。40名患者随机接受针灸治疗，46名患者接受标准治疗。患者在接受放疗的同一天接受治疗，每周3次。主观测量包括口干问卷（XQ）和MD安德森头颈部症状量表（MDASI-HN）。客观的措施是无刺激和刺激的全唾液流率（UWSFR; SSFR）。放疗结束后随访6个月。从第3周到6个月，针灸的XQ评分在统计学上显着低于对照组（第3周P = 0.003，所有其他P均<0.0001），临床显着差异如下：第11周-RR 0.63 [95%CI，0.45，0.87]; 6个月-RR 0.38 [95%CI，0.19，0.76]。MDASI-HN评分也观察到类似结果。早在治疗3周时，组间差异就出现了（UWSFR，P = 0.0004），针刺组在第7周（UWSFR，P <0.0001; SSFR，P = 0.002）和第11周（UWSFR，P <0.02; SSFR，P <0.03）以及6个月（SSFR，P <0.003）时的唾液流量更大。针灸配合放疗可明显减轻口干症，改善生活质量。
Xerostomia (dry mouth) after head/neck radiation is a common problem among cancer patients and available treatments are of little benefit. The objective of this trial was to determine if acupuncture can prevent xerostomia among head/neck patients undergoing radiotherapy. A randomized, controlled trial among patients with nasopharyngeal carcinoma was conducted comparing acupuncture to standard care. Participants were treated at Fudan University Shanghai Cancer Center, Shanghai, China. Forty patients were randomized to acupuncture treatment and 46 to standard care. Patients were treated 3 times/week on the same days they received radiotherapy. Subjective measures included the Xerostomia Questionnaire (XQ) and MD Anderson Symptom Inventory for Head/Neck (MDASI-HN). Objective measures were unstimulated and stimulated whole salivary flow rates (UWSFR; SSFR). Patients were followed for 6 months after the end of radiotherapy. XQ scores for acupuncture were statistically significantly lower than controls starting in week 3 through the 6-months(P=0.003 at week3, all other P’s < 0.0001), with clinically significant differences as follows: week 11- RR 0.63 [95% CI, 0.45, 0.87]; 6 months - RR 0.38 [95% CI, 0.19, 0.76]. Similar findings were seen for MDASI-HN scores. Group differences emerged as early as 3 weeks into treatment for saliva (UWSFR, P = 0.0004), with greater saliva flow in the acupuncture group at week 7 (UWSFR, P < 0.0001; SSFR, P = 0.002) and 11 (UWSFR, P < 0.02; SSFR, P < 0.03) and at 6 months (SSFR, P < 0.003). Acupuncture given concurrently with radiotherapy significantly reduced xerostomia and improved QOL.
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影响因子：
45.3
作者：
Brizel, DM;Wasserman, TH;Sauer, R
通讯作者：
Sauer, R
影响因子：
5.7
作者：
Chao, KSC;Majhail, N;Spector, G
通讯作者：
Spector, G
影响因子：
5.7
作者：
Horiot, JC;Lipinski, F;Maral, J
通讯作者：
Maral, J
影响因子：
2.6
作者：
Cho, Jung Hyo;Chung, Weon Kuu;Son, Chang Gue
通讯作者：
Son, Chang Gue
影响因子：
2.9
作者：
Dawidson, I;Angmar-Månsson, B;Lundeberg, T
通讯作者：
Lundeberg, T