Dissecting early life stress-induced adolescent depression through epigenomic approach.
Dissecting early life stress-induced adolescent depression through epigenomic approach.
复制标题
DOI：
10.1038/s41380-022-01907-x
复制
发表时间：
2023-01
影响因子：
11
通讯作者：
Dwivedi, Yogesh
中科院分区：
文献类型：
--
作者：
Ochi, Shinichiro;Dwivedi, Yogesh
早期生活压力（ELS），如童年时期的虐待和忽视，可能导致晚年的精神疾病。以往的研究表明，ELS可以通过表观遗传机制引起基因表达的深刻变化，这可能会导致成年期的精神疾病;然而，与ELS和青少年精神疾病相关的表观遗传修饰的研究有限。此外，这些表观遗传修饰如何导致青少年精神疾病还没有完全了解。通常，DNA甲基化、组蛋白修饰和非编码RNA的调节归因于与ELS相关的表观遗传学特征的重编程。虽然只有少数研究试图检查ELS青少年的表观遗传修饰，但现有证据表明，青少年和成人之间的表观遗传特征分析存在共性和差异。此外，表观遗传修饰具有性别依赖性，并受ELS类型的影响。在这篇综述中，我们批判性地评估了目前关于ELS青少年表观遗传修饰的证据，特别是临床前模型和人类的DNA甲基化和microRNA表达。我们还阐明了ELS对青少年精神疾病的影响，以预测神经精神疾病的发展，并通过个性化医疗预防和恢复这些疾病。
Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric disorders in later life. Previous studies have suggested that ELS can cause profound changes in gene expression through epigenetic mechanisms, which can lead to psychiatric disorders in adulthood; however, studies on epigenetic modifications associated with ELS and psychiatric disorders in adolescents are limited. Moreover, how these epigenetic modifications can lead to psychiatric disorders in adolescents is not fully understood. Commonly, DNA methylation, histone modification, and the regulation of noncoding RNAs have been attributed to the reprogramming of epigenetic profiling associated with ELS. Although only a few studies have attempted to examine epigenetic modifications in adolescents with ELS, existing evidence suggests that there are commonalities and differences in epigenetic profiling between adolescents and adults. In addition, epigenetic modifications are sex-dependent and are influenced by the type of ELS. In this review, we have critically evaluated the current evidence on epigenetic modifications in adolescents with ELS, particularly DNA methylation and the expression of microRNAs in both preclinical models and humans. We have also clarified the impact of ELS on psychiatric disorders in adolescents to predict the development of neuropsychiatric disorders and to prevent and recover these disorders through personalized medicine.
登录
查看更多内容
影响因子：
3.8
作者：
Anto, Marissa;Jaffee, Sara;Tietjen, Gretchen;Mendizabal, Adys;Szperka, Christina
通讯作者：
Szperka, Christina
影响因子：
25.8
作者：
Bjorkenstam, Emma;Hjern, Anders;Kosidou, Kyriaki
通讯作者：
Kosidou, Kyriaki
影响因子：
2.6
作者：
Aslund, Cecilia;Leppert, Jerzy;Nilsson, Kent W.
通讯作者：
Nilsson, Kent W.
影响因子：
4.5
作者：
Cattane, Nadia;Mora, Cristina;Cattaneo, Annamaria
通讯作者：
Cattaneo, Annamaria
影响因子：
2.3
作者：
Aytur, Semra A;Carlino, Sydney;Bernard, Felicity;West, Kelsi;Dobrzycki, Victoria;Malik, Riana
通讯作者：
Malik, Riana