Treatment Approaches to Moderate to Severe Psoriasis.

Treatment Approaches to Moderate to Severe Psoriasis.
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中度至重度银屑病的治疗方法。

DOI:
10.3390/ijms18112427
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发表时间:
2017-11-16
影响因子:
5.6
通讯作者:
Girolomoni G
Girolomoni G
中科院分区:
生物学2区
文献类型:
--
作者:
Gisondi P;Del Giglio M;Girolomoni G

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牛皮癣是一种常见疾病,对患者和医疗保健系统有相当大的影响。由于某些问题没有得到明确解决,该疾病的治疗方法可能多种多样。此外,由于最近批准了白介素 (IL)-17 抑制剂和阿普斯特等银屑病新疗法,治疗模式也在不断变化。在这篇综述中,影响银屑病严重程度的因素、全身治疗的适应症、治疗选择中要考虑的总体参数、生活方式干预以及对可用全身治疗的使用、筛选和监测的建议,包括阿维A、环孢素、甲氨蝶呤、阿普斯特、阿达木单抗、依那西普、英夫利昔单抗、苏金单抗、伊克斯克珠单抗和 讨论了乌司奴单抗。最后,报告了特殊患者群体的治疗方法,包括儿童、老年人、孕妇、有肿瘤病史的患者以及适合外科手术的患者。
Psoriasis is a common disease, which has a considerable impact on patients and the health care system. Treatment approaches to the disease may be various because some issues are not definitely addressed. Moreover, the therapeutic paradigms are continuously changing because of the recent approval of new treatments for psoriasis such as interleukin (IL)-17 inhibitors and apremilast. In this review, the factors influencing psoriasis severity, the indications for systemic treatments, the overall parameters to be considered in the treatment choice, life style interventions, and the recommendations for the use, screening, and monitoring of systemic therapies available including acitretin, cyclosporine, methotrexate, apremilast, adalimumab, etanercept, infliximab, secukinumab, ixekizumab, and ustekinumab are discussed. Finally, treatment approaches in special patient populations including children, the elderly, pregnant women, patients with a history of neoplasm, and candidates for surgical procedures are reported.
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