Nutrition and psoriasis: is there any association between the severity of the disease and adherence to the Mediterranean diet?
Nutrition and psoriasis: is there any association between the severity of the disease and adherence to the Mediterranean diet?
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DOI：
10.1186/s12967-014-0372-1
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发表时间：
2015-01-27
影响因子：
7.4
通讯作者：
Savastano S
中科院分区：
文献类型：
--
作者：
Barrea L;Balato N;Di Somma C;Macchia PE;Napolitano M;Savanelli MC;Esposito K;Colao A;Savastano S
许多研究已经评估了个体营养在银屑病发展中的作用。然而，很少有研究调查健康饮食模式的影响，比如地中海饮食。在这项研究中，我们旨在调查一组单纯治疗的银屑病患者对地中海饮食的坚持、身体成分和银屑病严重程度之间的关系。这是一项横断面病例对照观察性研究。62例轻、重度银屑病患者，男49例，女13例，平均年龄(50.2±10.5)岁。62名年龄、性别和体重指数(BMI)匹配的健康受试者作为对照组。一份有效的14项问卷(PREDIMED：Prevención con Dieta地中海)被用于评估对地中海饮食的遵守情况。通过标准化银屑病面积和严重程度指数(PASI)评分和C反应蛋白(CRP)水平评估银屑病的严重程度。用生物电阻抗分析仪分析其身体成分。与对照组相比，银屑病患者的PREDIMED评分较低(30.6%比4.8%)。PASI评分与脂肪质量百分比(Fm%)和C反应蛋白水平显著相关。PASI评分和CRP水平与PREDIMED问卷中的饮食成分或PREDIMED评分显著相关。在多元回归分析中，影响PASI评分的主要因素是BIA参数中的FM(R2=0.537，β=0.740，p<；0.001)，以及人体测量、FM和PREDIMED评分中的FM(R2=0.537，β=0.603，p<；0.001)和PREDIMED评分(R2=0.599，β=−0.296，p=0.007)。最后，在PREDIMED问卷的所有条目中，EVOO(R2=0.548，β=−0.741，p<；0.001)和鱼的摄入量(R2=0.139，β=−0.372，p=0.005)对PASI评分和C反应蛋白水平有独立的预测值。这是第一次评估坚持地中海饮食和牛皮癣严重程度之间的联系的研究。此外，我们的研究强调了通过生物电阻抗分析评估身体成分在评估银屑病患者中的作用。
Many studies have evaluated the role of individual nutrients on the development of psoriasis. However, only few studies have investigated the effect of a healthy eating pattern, such as the Mediterranean diet. In this study, we aimed to investigate the relationship between adherence to the Mediterranean diet, the body composition and the severity of psoriasis in a group of naïve-treatment patients with psoriasis. This is a cross-sectional case–control observational study. Sixty-two patients (49 males and 13 females, mean age: 50.2±10.5yrs) affected with mild-to-severe psoriasis were consecutively enrolled. Sixty-two age-, sex- and body mass index (BMI)-matched healthy subjects served as control group. A validated 14-item questionnaire (PREDIMED: PREvención con DIeta MEDiterránea) was used for the assessment of adherence to the Mediterranean diet. The severity of psoriasis was by assessed by standardized Psoriasis Area and Severity Index (PASI) score and C-reactive protein (CRP) levels. Body composition was analyzed with bioelectrical impedance analysis. A higher percentage of psoriatic patients had a lower PREDIMED score compared to the control group (30.6% vs 4.8%). PASI score was significantly associated with the percentage of fat mass (FM%) and CRP levels. PASI score and CRP levels were significantly associated with the dietary components included in the PREDIMED questionnaire or with the PREDIMED score. At multiple regression analysis, the major predictor of PASI score were FM among BIA parameters, (r2=0.537, β=0.740, p<0.001), and FM (r2=0.537, β=0.603, p<0.001) and PREDIMED score (r2=0.599, β=−0.296, p=0.007) among anthropometric measures, FM and PREDIMED score. Finally, among all items of the PREDIMED questionnaire, EVOO (r2=0.548, β=−0.741, p<0.001), and fish consumption (r2=0.139, β=−0.372, p=0.005) have an independent predictive value for PASI score and CRP levels. This is the first study to evaluate the association between adherence to the Mediterranean diet and the severity of psoriasis. Moreover, our study highlights the usefulness of the assessment of body composition by bioelectrical impedance analysis in the evaluation of the psoriatic patients.
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影响因子：
13.8
作者：
Debbaneh, Maya;Millsop, Jillian W.;Bhatia, Bhavnit K.;Koo, John;Liao, Wilson
通讯作者：
Liao, Wilson
影响因子：
3.6
作者：
Engin, Burhan;Kutlubay, Zekayi;Tuzun, Yalcin
通讯作者：
Tuzun, Yalcin
影响因子：
3.5
作者：
Cicerale, Sara;Breslin, Paul A. S.;Keast, Russell S. J.
通讯作者：
Keast, Russell S. J.
影响因子：
2.1
作者：
Esposito, Katherine;Di Palo, Carmen;Giugliano, Dario
通讯作者：
Giugliano, Dario
影响因子：
3.5
作者：
De Lorenzo, Antonino;Bianchi, Alessia;Di Renzo, Laura
通讯作者：
Di Renzo, Laura