Taurine protects dopaminergic neurons in a mouse Parkinson's disease model through inhibition of microglial M1 polarization.
Taurine protects dopaminergic neurons in a mouse Parkinson's disease model through inhibition of microglial M1 polarization.
复制标题
牛磺酸通过抑制小胶质细胞M1极化来保护帕金森病小鼠模型中的多巴胺能神经元。
DOI：
10.1038/s41419-018-0468-2
复制
发表时间：
2018-04-01
影响因子：
9
通讯作者：
Wang Q
中科院分区：
文献类型：
--
作者：
Che Y;Hou L;Sun F;Zhang C;Liu X;Piao F;Zhang D;Li H;Wang Q
Microglia-mediated neuroinflammation is implicated in multiple neurodegenerative disorders, including Parkinson’s disease (PD). Hence, the modulatioein of sustained microglial activation may have therapeutic potential. This study is designed to test the neuroprotective efficacy of taurine, a major intracellular free β-amino acid in mammalian tissues, by using paraquat and maneb-induced PD model. Results showed that mice intoxicated with paraquat and maneb displayed progressive dopaminergic neurodegeneration and motor deficits, which was significantly ameliorated by taurine. Taurine also attenuated the aggregation of α-synuclein in paraquat and maneb-intoxicated mice. Mechanistically, taurine suppressed paraquat and maneb-induced microglial activation. Moreover, depletion of microglia abrogated the dopaminergic neuroprotective effects of taurine, revealing the role of microglial activation in taurine-afforded neuroprotection. Subsequently, we found that taurine suppressed paraquat and maneb-induced microglial M1 polarization and gene expression levels of proinflammatory factors. Furthermore, taurine was shown to be able to inhibit the activation of NADPH oxidase (NOX2) by interfering with membrane translocation of cytosolic subunit, p47phox and nuclear factor-kappa B (NF-κB) pathway, two key factors for the initiation and maintenance of M1 microglial inflammatory response. Altogether, our results showed that taurine exerted dopaminergic neuroprotection through inactivation of microglia-mediated neuroinflammation, providing a promising avenue and candidate for the potential therapy for patients suffering from PD.
登录
查看更多内容
姜黄素通过滴定小胶质细胞/巨噬细胞极化来预防缺血性中风
影响因子：
4.8
作者：
Liu Z;Ran Y;Huang S;Wen S;Zhang W;Liu X;Ji Z;Geng X;Ji X;Du H;Leak RK;Hu X
通讯作者：
Hu X
影响因子：
4.7
作者：
Choi SH;Aid S;Kim HW;Jackson SH;Bosetti F
通讯作者：
Bosetti F
DOI：
10.1007/978-1-62703-520-0_21
发表时间：
2013
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Chen SH;Oyarzabal EA;Hong JS
通讯作者：
Hong JS
影响因子：
3.3
作者：
Javed, Hayate;Khan, Andleeb;Islam, Fakhrul
通讯作者：
Islam, Fakhrul
影响因子：
4.5
作者：
Hou, Liyan;Zhang, Cong;Wang, Qingshan
通讯作者：
Wang, Qingshan