The effects of short-term vitamin D supplementation on glucose metabolism in dialysis patients: a systematic review and meta-analysis.
The effects of short-term vitamin D supplementation on glucose metabolism in dialysis patients: a systematic review and meta-analysis.
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DOI：
10.1007/s11255-015-0909-0
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发表时间：
2015-03
影响因子：
2
通讯作者：
Melamed, Michal L.
中科院分区：
文献类型：
--
作者：
Sarathy, Harini;Pramanik, Vedatrayee;Kahn, Jared;Abramowitz, Matthew K.;Meier, Kristen;Kishore, Preeti;Melamed, Michal L.
We tested whether short-term vitamin D supplementation improves insulin resistance in patients with kidney disease, a condition with little intrinsic vitamin D activity. PubMed, Embase and CENTRAL were searched for relevant observational studies and randomized clinical trials (RCTs). Random effects models were employed for meta-analysis and effect sizes were summarized as standardized mean difference (SMD) with 95% confidence intervals. Separate analyses were done for RCTs and non-randomized intervention studies (NRIS). Seventeen studies (5 RCTs and 12 NRIS) were included. The meta-analysis population (n=131) was mostly middle aged (40–50 years), male and non-diabetic, and on hemodialysis. The duration (4–12 weeks) and type of supplementation varied between studies. Among RCTs, compared to placebo, vitamin D supplementation was associated with significant decrease in fasting glucose [SMD −1.13,( −2.11 to −0.11)] and PTH levels [SMD −1.50,(−2.95 to −0.04)] but no difference in fasting insulin levels [SMD 1.32, (−0.15 to 2.79). Among NRIS, there was only a significant decrease in PTH levels [SMD −1.68, (−2.55 to −0.82)] between pre and post-vitamin D treatment levels. Short term (4–12 weeks) supplementation with vitamin D is associated with lower fasting glucose levels in ESRD with no change in fasting insulin levels. However, the findings from this study are limited by the studies that were used in the meta-analysis, which were mostly small, used multiple different vitamin D compounds and dosing regimens, had large heterogeneity and funnel plots showed there was a dearth of studies with null or negative finding. Therefore, larger randomized clinical trials need to be performed to answer this important clinical question.
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影响因子：
3
作者：
Furlan, Andrea D.;Pennick, Victoria;van Tulder, Maurits
通讯作者：
van Tulder, Maurits
DOI：
10.1080/00365599.1988.11690415
发表时间：
1988-01-01
影响因子：
--
作者：
LIND, L;LITHELL, H;LJUNGHALL, S
通讯作者：
LJUNGHALL, S
影响因子：
19.6
作者：
通讯作者：
--
影响因子：
3.2
作者：
Blair, Debra;Byham-Gray, Laura;McCaffrey, Susan
通讯作者：
McCaffrey, Susan
影响因子：
19.6
作者：
Fliser, D;Pacini, G;Ritz, E
通讯作者：
Ritz, E