Microporous Biodegradable Films Promote Therapeutic Angiogenesis.
Microporous Biodegradable Films Promote Therapeutic Angiogenesis.
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DOI：
10.1002/adhm.202000806
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发表时间：
2020-09
影响因子：
10
通讯作者：
Day RM
中科院分区：
文献类型：
--
作者：
Hendow EK;Moazen M;Iacoviello F;Bozec L;Pellet-Many C;Day RM
Peripheral arterial disease and critical limb ischemia are common symptoms of cardiovascular disease. Vascular surgery is used to create a bypass around occluded blood vessels to improve blood flow to ischemic muscle, thus avoiding the need for amputation. Attempts to vascularize tissues by therapeutic angiogenesis using delivery of exogenous angiogenic agents are underwhelming. A material‐based approach that provides an endogenous stimulus capable of promoting angiogenesis and increased tissue perfusion would provide a paradigm shift in treatment options available. It is reported here that microporous biodegradable films produced using thermally induced phase separation provide a localized biophysical stimulus of proangiogenic genes in vivo that is associated with increased blood vessel density and restoration of blood flow to ischemic tissue. These findings show, for the first time, that acellular, nonfunctionalized biodegradable biomaterials can provide an innovative, material‐based approach for therapeutic angiogenesis to enhance tissue reperfusion in vivo. Microporous biodegradable film produced using thermally induced phase separation is developed to promote therapeutic angiogenesis for cardiovascular disease. The film stimulates restoration of vascular perfusion in ischemic tissue via upregulation of proangiogenic growth genes that result in increased vessel in density. The new material has potential transform treatment of cardiovascular disease.
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影响因子：
14
作者：
Chen, Sulin;Jones, Jacqueline A.;Xu, Yongan;Low, Hong-Yee;Anderson, James M.;Leong, Kam W.
通讯作者：
Leong, Kam W.
DOI：
10.1152/ajpheart.00094.2008
发表时间：
2008-08
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Carr CA;Stuckey DJ;Tatton L;Tyler DJ;Hale SJ;Sweeney D;Schneider JE;Martin-Rendon E;Radda GK;Harding SE;Watt SM;Clarke K
通讯作者：
Clarke K
影响因子：
3.1
作者：
DeQuach JA;Lin JE;Cam C;Hu D;Salvatore MA;Sheikh F;Christman KL
通讯作者：
Christman KL
影响因子：
168.9
作者：
Fowkes, F. Gerald R.;Rudan, Diana;Criqui, Michael H.
通讯作者：
Criqui, Michael H.
影响因子：
4.1
作者：
Keshaw, Hussila;Georgiou, George;Day, Richard M.
通讯作者：
Day, Richard M.